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Cutaneous bacteria of the redback salamander prevent morbidity associated with a lethal disease

Becker, Matthew H ; Harris, Reid N Johnson, Stephen J.

PloS one, 2010-06, Vol.5 (6), p.e10957-e10957 [Periódico revisado por pares]

United States: Public Library of Science

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Título:
Cutaneous bacteria of the redback salamander prevent morbidity associated with a lethal disease
Autor: Becker, Matthew H ; Harris, Reid N
Johnson, Stephen J.
Assuntos: Acidification ; Amphibia ; Amphibians ; Animals ; Antibiotics ; Bacteria ; Bacteria - isolation & purification ; Batrachochytrium dendrobatidis ; Body mass ; Candida ; Candida albicans ; Caudata ; Chytridiomycosis ; Communicable diseases ; Communities ; Disease ; Disease resistance ; Ecology ; Ecology/Conservation and Restoration Ecology ; Ecology/Environmental Microbiology ; Frogs ; Fungi ; Hemidactylium scutatum ; Homarus americanus ; Hypotheses ; Infectious Diseases ; Infectious Diseases/Epidemiology and Control of Infectious Diseases ; Infectious Diseases/Fungal Infections ; Lactobacillus ; Lethal effects ; Metabolites ; Morbidity ; Mortality ; Mutualism ; Mycoses - prevention & control ; Plethodon cinereus ; Population decline ; Rana muscosa ; Reptiles & amphibians ; Skin ; Skin - microbiology ; Skin diseases ; Urodela - microbiology
É parte de: PloS one, 2010-06, Vol.5 (6), p.e10957-e10957
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Conceived and designed the experiments: MHB RNH. Performed the experiments: MHB RNH. Analyzed the data: MHB RNH. Contributed reagents/materials/analysis tools: MHB RNH. Wrote the paper: MHB RNH.
Descrição: Chytridiomycosis, caused by the fungal pathogen Batrachochytrium dendrobatidis (Bd), is an infectious disease that causes population declines of many amphibians. Cutaneous bacteria isolated from redback salamanders, Plethodon cinereus, and mountain yellow-legged frogs, Rana muscosa, inhibit the growth of Bd in vitro. In this study, the bacterial community present on the skin of P. cinereus individuals was investigated to determine if it provides protection to salamanders from the lethal and sub-lethal effects of chytridiomycosis. When the cutaneous bacterial community was reduced prior to Bd exposure, salamanders experienced a significantly greater decrease in body mass, which is a symptom of the disease, when compared to infected individuals with a normal bacterial community. In addition, a greater proportion of infected individuals with a reduced bacterial community experienced limb-lifting, a behavior seen only in infected individuals. Overall, these results demonstrate that the cutaneous bacterial community of P. cinereus provides protection to the salamander from Bd and that alteration of this community can change disease resistance. Therefore, symbiotic microbes associated with this species appear to be an important component of its innate skin defenses.
Editor: United States: Public Library of Science
Idioma: Inglês

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Cutaneous bacteria of the redback salamander prevent morbidity associated with a lethal disease

Becker, Matthew H ; Harris, Reid N Johnson, Stephen J.

United States: Public Library of Science

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