Idioma:

Dialkylation of Indoles with Trichloroacetimidates to Access 3,3-Disubstituted Indolenines

Suzuki, Tamie ; Mate, Nilamber A ; Adhikari, Arijit A ; Chisholm, John D

Molecules (Basel, Switzerland), 2019-11, Vol.24 (22), p.4143 [Periódico revisado por pares]

Texto completo disponível

Citações Citado por

Título:
Dialkylation of Indoles with Trichloroacetimidates to Access 3,3-Disubstituted Indolenines
Autor: Suzuki, Tamie ; Mate, Nilamber A ; Adhikari, Arijit A ; Chisholm, John D
Assuntos: Acetamides - chemistry ; Acids ; Catalysis ; Chloroacetates - chemistry ; dialkylation ; indole ; indolenine ; Indoles ; Indoles - chemistry ; Investigations ; Lewis acid ; Lewis Acids - chemistry ; Natural products ; Pharmaceutical sciences ; spiroindoline ; Stereoisomerism ; Transition metals ; trichloroacetimidate
É parte de: Molecules (Basel, Switzerland), 2019-11, Vol.24 (22), p.4143
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: 2-Substituted indoles may be directly transformed to 3,3-dialkyl indolenines with trichloroacetimidate electrophiles and the Lewis acid TMSOTf. These reactions provide rapid access to complex indolenines which are present in a variety of complex natural products and medicinally relevant small molecule structures. This method provides an alternative to the use of transition metal catalysis. The indolenines are readily transformed into spiroindoline systems which are privileged scaffolds in medicinal chemistry.
Editor: Switzerland: MDPI AG
Idioma: Inglês

Links

Voltar para lista de resultados