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Seroprevalence of 34 human papillomavirus types in the German general population

Michael, Kristina M ; Waterboer, Tim ; Sehr, Peter ; Rother, Annette ; Reidel, Ulrich ; Boeing, Heiner ; Bravo, Ignacio G ; Schlehofer, Jörg ; Gärtner, Barbara C ; Pawlita, Michael Schiller, John T.

PLoS pathogens, 2008-06, Vol.4 (6), p.e1000091-e1000091 [Periódico revisado por pares]

United States: Public Library of Science

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Título:
Seroprevalence of 34 human papillomavirus types in the German general population
Autor: Michael, Kristina M ; Waterboer, Tim ; Sehr, Peter ; Rother, Annette ; Reidel, Ulrich ; Boeing, Heiner ; Bravo, Ignacio G ; Schlehofer, Jörg ; Gärtner, Barbara C ; Pawlita, Michael
Schiller, John T.
Assuntos: Adolescent ; Adult ; Age Factors ; Aged ; Aged, 80 and over ; Cervical cancer ; Child ; Child, Preschool ; Diagnosis ; Female ; Germany - epidemiology ; Health aspects ; Human papillomavirus ; Humans ; Infant ; Infectious Diseases/Epidemiology and Control of Infectious Diseases ; Infectious Diseases/Gynecologic Infections ; Infectious Diseases/Sexually Transmitted Diseases ; Infectious Diseases/Skin Infections ; Infectious Diseases/Viral Infections ; Male ; Microbiology/Immunity to Infections ; Microbiology/Medical Microbiology ; Middle Aged ; Mucous Membrane - virology ; Papillomaviridae - isolation & purification ; Papillomavirus infections ; Papillomavirus Infections - epidemiology ; Papillomaviruses ; Prevalence studies (Epidemiology) ; Proteins ; Public Health and Epidemiology/Infectious Diseases ; Risk factors ; Seroepidemiologic Studies ; Sex Factors ; Skin cancer ; Skin Diseases, Viral ; Virology/Host Antiviral Responses
É parte de: PLoS pathogens, 2008-06, Vol.4 (6), p.e1000091-e1000091
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Conceived and designed the experiments: JS MP. Performed the experiments: KM TW. Analyzed the data: KM TW PS IB MP. Contributed reagents/materials/analysis tools: KM TW PS AR UR HB IB BG. Wrote the paper: KM. Drafted the article: KM MP. Critically revised the article: TW PS AR UR HB IB JS BG MP.
d: Current address: Institute for Evolution and Biodiversity, Experimental Molecular Evolution Group, Westfälische Wilhelms University, Münster, Germany
a: Current address: Joint DKFZ-EMBL Chemical Biology Core Facility, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany
c: Current address: Department of Dermatology und Allergology, Klinikum Augsburg Süd, Augsburg, Germany
b: Current address: University Children's Hospital, Heidelberg, Germany
Descrição: The natural history of infections with many human papillomavirus (HPV) types is poorly understood. Here, we describe for the first time the age- and sex-dependent antibody prevalence for 29 cutaneous and five mucosal HPV types from 15 species within five phylogenetic genera (alpha, beta, gamma, mu, nu) in a general population. Sera from 1,797 German adults and children (758 males and 1,039 females) between 1 and 82 years (median 37 years) were analysed for antibodies to the major capsid protein L1 by Luminex-based multiplex serology. The first substantial HPV antibody reactions observed already in children and young adults are those to cutaneous types of the genera nu (HPV 41) and mu (HPV 1, 63). The antibody prevalence to mucosal high-risk types, most prominently HPV 16, was elevated after puberty in women but not in men and peaked between 25 and 34 years. Antibodies to beta and gamma papillomaviruses (PV) were rare in children and increased homogeneously with age, with prevalence peaks at 40 and 60 years in women and 50 and 70 years in men. Antibodies to cutaneous alpha PV showed a heterogeneous age distribution. In summary, these data suggest three major seroprevalence patterns for HPV of phylogenetically distinct genera: antibodies to mu and nu skin PV appear early in life, those to mucosal alpha PV in women after puberty, and antibodies to beta as well as to gamma skin PV accumulate later in life.
Editor: United States: Public Library of Science
Idioma: Inglês

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Seroprevalence of 34 human papillomavirus types in the German general population

Michael, Kristina M ; Waterboer, Tim ; Sehr, Peter ; Rother, Annette ; Reidel, Ulrich ; Boeing, Heiner ; Bravo, Ignacio G ; Schlehofer, Jörg ; Gärtner, Barbara C ; Pawlita, Michael Schiller, John T.

United States: Public Library of Science

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