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Modulation of antioxidant and detoxification responses mediated by lipoic acid in the fish Corydoras paleatus (Callychthyidae)

Monserrat, José Maria ; Lima, Juliane Ventura ; Ferreira, Josencler Luis Ribas ; Acosta, Daiane ; Garcia, Márcia Longaray ; Ramos, Patricia Baptista ; Moraes, Tarsila Barros ; dos Santos, Luciane Cougo ; Amado, Lílian Lund

Comparative biochemistry and physiology. Toxicology & pharmacology, 2008-09, Vol.148 (3), p.287-292 [Periódico revisado por pares]

United States: Elsevier Inc

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Título:
Modulation of antioxidant and detoxification responses mediated by lipoic acid in the fish Corydoras paleatus (Callychthyidae)
Autor: Monserrat, José Maria ; Lima, Juliane Ventura ; Ferreira, Josencler Luis Ribas ; Acosta, Daiane ; Garcia, Márcia Longaray ; Ramos, Patricia Baptista ; Moraes, Tarsila Barros ; dos Santos, Luciane Cougo ; Amado, Lílian Lund
Assuntos: Animals ; Antioxidant system ; Antioxidants - pharmacology ; Antioxidants - therapeutic use ; Brain - drug effects ; Brain - metabolism ; Catfishes - metabolism ; Fish ; Gills - drug effects ; Gills - metabolism ; Glutamate-cysteine ligase ; Glutamate-Cysteine Ligase - metabolism ; Glutathione Reductase - metabolism ; Glutathione Transferase - metabolism ; Glutathione-S-transferase ; Lipoic acid ; Liver - drug effects ; Liver - metabolism ; Muscles - drug effects ; Muscles - metabolism ; Protein oxidation ; Reactive Oxygen Species - metabolism ; Thioctic Acid - pharmacology ; Thioctic Acid - therapeutic use
É parte de: Comparative biochemistry and physiology. Toxicology & pharmacology, 2008-09, Vol.148 (3), p.287-292
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
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Descrição: Lipoic acid (LA) has been reported as a potential therapeutic agent due its antioxidants proprieties. It was considered its effect in different organs (gills, brain, muscle and liver) of the fish Corydoras paleatus (Callychthyidae). LA (70 mg/kg of body mass) was added to a commercial fish diet, organisms being fed daily (1% body weight). Sixty animals (mean mass: 2.37 ± 0.09 g) were placed randomly in aquariums and received (+ LA) or not (− LA) lipoic acid enriched diet during four weeks. After, fish were killed and the brain, muscle, gills and liver were dissected. LA treatment reduced significantly ( p < 0.05) reactive oxygen species concentration in brain and increased ( p < 0.05) glutamate-cysteine ligase activity in brain and liver of the same experimental group. LA fed organisms showed higher ( p < 0.05) brain glutathione-S-transferase activity, indicating that LA improves the detoxification and antioxidant capacity face components that waste glutathione in phase II reactions. A conspicuous reduction of protein oxidation was observed in muscle and liver of + LA organisms, indicating that the treatment was also effective in reducing oxidative stress parameters.
Editor: United States: Elsevier Inc
Idioma: Inglês

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Modulation of antioxidant and detoxification responses mediated by lipoic acid in the fish Corydoras paleatus (Callychthyidae)

Monserrat, José Maria ; Lima, Juliane Ventura ; Ferreira, Josencler Luis Ribas ; Acosta, Daiane ; Garcia, Márcia Longaray ; Ramos, Patricia Baptista ; Moraes, Tarsila Barros ; dos Santos, Luciane Cougo ; Amado, Lílian Lund

United States: Elsevier Inc

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