Idioma:

Ultrasound-Stimulated Phase-Change Contrast Agents for Transepithelial Delivery of Macromolecules, Toward Gastrointestinal Drug Delivery

Fix, Samantha M. ; Koppolu, Bhanu P. ; Novell, Anthony ; Hopkins, Jared ; Kierski, Thomas M. ; Zaharoff, David A. ; Dayton, Paul A. ; Papadopoulou, Virginie

Ultrasound in medicine & biology, 2019-07, Vol.45 (7), p.1762-1776 [Periódico revisado por pares]

England: Elsevier Inc

Texto completo disponível

Citações Citado por

Enviar para

Título:
Ultrasound-Stimulated Phase-Change Contrast Agents for Transepithelial Delivery of Macromolecules, Toward Gastrointestinal Drug Delivery
Autor: Fix, Samantha M. ; Koppolu, Bhanu P. ; Novell, Anthony ; Hopkins, Jared ; Kierski, Thomas M. ; Zaharoff, David A. ; Dayton, Paul A. ; Papadopoulou, Virginie
Assuntos: Acoustic droplet vaporization ; Acoustics ; Cells, Cultured ; Contrast Media ; Dextrans - administration & dosage ; Drug Delivery Systems - methods ; Engineering Sciences ; Fluorescein-5-isothiocyanate - administration & dosage ; Fluorescein-5-isothiocyanate - analogs & derivatives ; Gastrointestinal Agents - administration & dosage ; Humans ; Image Enhancement - methods ; In Vitro Techniques ; Life Sciences ; Nanodroplet ; Pharmaceutical sciences ; Pharmacology ; Phase-change contrast agents ; Transepithelial delivery ; Ultrasonography - methods ; Ultrasound
É parte de: Ultrasound in medicine & biology, 2019-07, Vol.45 (7), p.1762-1776
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: The gastrointestinal (GI) tract presents a notoriously difficult barrier for macromolecular drug delivery, especially for biologics. Herein, we demonstrate that ultrasound-stimulated phase change contrast agents (PCCAs) can transiently disrupt confluent colorectal adenocarcinoma monolayers and improve the transepithelial transport of a macromolecular model drug. With ultrasound treatment in the presence of PCCAs, we achieved a maximum of 44 ± 15% transepithelial delivery of 70-kDa fluorescein isothiocyanate-dextran, compared with negligible delivery through sham control monolayers. Among all tested rarefactional pressures (300–600 kPa), dextran delivery efficiency was consistently greatest at 300 kPa. To explore this unexpected finding, we quantified stable and inertial cavitation energy generated by various ultrasound exposure conditions. In general, lower pressures resulted in more persistent cavitation activity during the 30-s ultrasound exposures, which may explain the enhanced dextran delivery efficiency. Thus, a unique advantage of using low boiling point PCCAs for this application is that the same low-pressure pulses can be used to induce vaporization and provide maximal delivery.
Editor: England: Elsevier Inc
Idioma: Inglês

Links

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

Ultrasound-Stimulated Phase-Change Contrast Agents for Transepithelial Delivery of Macromolecules, Toward Gastrointestinal Drug Delivery

Fix, Samantha M. ; Koppolu, Bhanu P. ; Novell, Anthony ; Hopkins, Jared ; Kierski, Thomas M. ; Zaharoff, David A. ; Dayton, Paul A. ; Papadopoulou, Virginie

England: Elsevier Inc

Buscando em bases de dados remotas. Favor aguardar.