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Hyperoxia, hypocapnia and hypercapnia as outcome factors after cardiac arrest in children

del Castillo, Jimena ; López-Herce, Jesús ; Matamoros, Martha ; Cañadas, Sonia ; Rodriguez-Calvo, Ana ; Cechetti, Corrado ; Rodriguez-Núñez, Antonio ; Álvarez, Angel Carrillo

Resuscitation, 2012-12, Vol.83 (12), p.1456-1461 [Periódico revisado por pares]

Ireland: Elsevier Ireland Ltd

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Título:
Hyperoxia, hypocapnia and hypercapnia as outcome factors after cardiac arrest in children
Autor: del Castillo, Jimena ; López-Herce, Jesús ; Matamoros, Martha ; Cañadas, Sonia ; Rodriguez-Calvo, Ana ; Cechetti, Corrado ; Rodriguez-Núñez, Antonio ; Álvarez, Angel Carrillo
Assuntos: Adolescent ; Cardiac arrest ; Cardiopulmonary Resuscitation ; Child ; Child, Preschool ; Children ; Emergency ; Female ; Heart Arrest - complications ; Heart Arrest - mortality ; Heart Arrest - therapy ; Humans ; Hypercapnia ; Hypercapnia - epidemiology ; Hypercapnia - etiology ; Hyperoxia ; Hyperoxia - epidemiology ; Hyperoxia - etiology ; Hypocapnia ; Hypocapnia - epidemiology ; Hypocapnia - etiology ; Hypoxia ; Incidence ; Infant ; Male ; Prospective Studies
É parte de: Resuscitation, 2012-12, Vol.83 (12), p.1456-1461
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
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Descrição: Abstract Purpose Arterial hyperoxia after resuscitation has been associated with increased mortality in adults. The aim of this study was to test the hypothesis that post-resuscitation hyperoxia and hypocapnia are associated with increased mortality after resuscitation in pediatric patients. Methods We performed a prospective observational multicenter hospital-based study including 223 children aged between 1 month and 18 years who achieved return of spontaneous circulation after in-hospital cardiac arrest and for whom arterial blood gas analysis data were available. Results After return of spontaneous circulation, 8.5% of patients had hyperoxia (defined as PaO2 > 300 mmHg) and 26.5% hypoxia (defined as PaO2 < 60 mmHg). No statistical differences in mortality were observed when patients with hyperoxia (52.6%), hypoxia (42.4%), or normoxia (40.7%) ( p = 0.61). Hypocapnia (defined as PaCO2 < 30 mmHg) was observed in 13.5% of patients and hypercapnia (defined as PaCO2 > 50 mmHg) in 27.6%. Patients with hypercapnia or hypocapnia had significantly higher mortality (59.0% and 50.0%, respectively) than patients with normocapnia (33.1%) ( p = 0.002). At 24 h after return of spontaneous circulation, neither PaO2 nor PaCO2 values were associated with mortality. Multiple logistic regression analysis showed that hypercapnia (OR, 3.27; 95% CI, 1.62–6.61; p = 0.001) and hypocapnia (OR, 2.71; 95% CI, 1.04–7.05; p = 0.04) after return of spontaneous circulation were significant mortality factors. Conclusions In children resuscitated from cardiac arrest, hyperoxemia after return of spontaneous circulation or 24 h later was not associated with mortality. On the other hand, hypercapnia and hypocapnia were associated with higher mortality than normocapnia.
Editor: Ireland: Elsevier Ireland Ltd
Idioma: Inglês

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Hyperoxia, hypocapnia and hypercapnia as outcome factors after cardiac arrest in children

del Castillo, Jimena ; López-Herce, Jesús ; Matamoros, Martha ; Cañadas, Sonia ; Rodriguez-Calvo, Ana ; Cechetti, Corrado ; Rodriguez-Núñez, Antonio ; Álvarez, Angel Carrillo

Ireland: Elsevier Ireland Ltd

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