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Post-pandemic influenza A/H1N1pdm09 is associated with more severe outcomes than A/H3N2 and other respiratory viruses in adult hospitalisations

Minney-Smith, C A ; Selvey, L A ; Levy, A ; Smith, D W

Epidemiology and infection, 2019-11, Vol.147, p.e310-e310, Article e310 [Periódico revisado por pares]

England: Cambridge University Press

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Título:
Post-pandemic influenza A/H1N1pdm09 is associated with more severe outcomes than A/H3N2 and other respiratory viruses in adult hospitalisations
Autor: Minney-Smith, C A ; Selvey, L A ; Levy, A ; Smith, D W
Assuntos: Adolescent ; Adult ; Aged ; Aged, 80 and over ; Female ; Hospitalization ; Humans ; Influenza A Virus, H1N1 Subtype - isolation & purification ; Influenza A Virus, H1N1 Subtype - pathogenicity ; Influenza A Virus, H3N2 Subtype - isolation & purification ; Influenza A Virus, H3N2 Subtype - pathogenicity ; Influenza, Human - diagnosis ; Influenza, Human - epidemiology ; Influenza, Human - therapy ; Influenza, Human - virology ; Logistic Models ; Male ; Middle Aged ; Original Paper ; Pandemics ; Prognosis ; Proportional Hazards Models ; Retrospective Studies ; Severity of Illness Index ; Western Australia - epidemiology ; Young Adult
É parte de: Epidemiology and infection, 2019-11, Vol.147, p.e310-e310, Article e310
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: This study compares the frequency and severity of influenza A/H1N1pdm09 (A/H1), influenza A/H3N2 (A/H3) and other respiratory virus infections in hospitalised patients. Data from 17 332 adult hospitalised patients admitted to Sir Charles Gairdner Hospital, Perth, Western Australia, with a respiratory illness between 2012 and 2015 were linked with data containing reverse transcription polymerase chain reaction results for respiratory viruses including A/H1, A/H3, influenza B, human metapneumovirus, respiratory syncytial virus and parainfluenza. Of these, 1753 (10.1%) had test results. Multivariable regression analyses were conducted to compare the viruses for clinical outcomes including ICU admission, ventilation, pneumonia, length of stay and death. Patients with A/H1 were more likely to experience severe outcomes such as ICU admission (OR 2.5, 95% CI 1.2-5.5, P = 0.016), pneumonia (OR 3.0, 95% CI 1.6-5.7, P < 0.001) and lower risk of discharge from hospital (indicating longer lengths of hospitalisation; HR 0.64 95% CI 0.47-0.88, P = 0.005), than patients with A/H3. Patients with a non-influenza respiratory virus were less likely to experience severe clinical outcomes than patients with A/H1, however, had similar likelihood when compared to patients with A/H3. Patients hospitalised with A/H1 had higher odds of severe outcomes than patients with A/H3 or other respiratory viruses. Knowledge of circulating influenza strains is important for healthcare preparedness.
Editor: England: Cambridge University Press
Idioma: Inglês

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Post-pandemic influenza A/H1N1pdm09 is associated with more severe outcomes than A/H3N2 and other respiratory viruses in adult hospitalisations

Minney-Smith, C A ; Selvey, L A ; Levy, A ; Smith, D W

England: Cambridge University Press

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