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miRNAs driving diagnosis, prognosis and progression in Merkel cell carcinoma

AL-Noshokaty, Tohada M. ; Elballal, Mohammed S. ; Helal, Gouda Kamel ; Abulsoud, Ahmed I. ; Elshaer, Shereen Saeid ; El-Husseiny, Ahmed A. ; Fathi, Doaa ; Abdelmaksoud, Nourhan M. ; Abdel Mageed, Sherif S. ; Midan, Heba M. ; Zaki, Mohamed Bakr ; Abd-Elmawla, Mai A. ; Rizk, Nehal I. ; Elrebehy, Mahmoud A. ; Zewail, Moataz B. ; Mohammed, Osama A. ; Doghish, Ahmed S.

Pathology, research and practice, 2023-09, Vol.249, p.154763-154763, Article 154763 [Periódico revisado por pares]

Elsevier GmbH

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Título:
miRNAs driving diagnosis, prognosis and progression in Merkel cell carcinoma
Autor: AL-Noshokaty, Tohada M. ; Elballal, Mohammed S. ; Helal, Gouda Kamel ; Abulsoud, Ahmed I. ; Elshaer, Shereen Saeid ; El-Husseiny, Ahmed A. ; Fathi, Doaa ; Abdelmaksoud, Nourhan M. ; Abdel Mageed, Sherif S. ; Midan, Heba M. ; Zaki, Mohamed Bakr ; Abd-Elmawla, Mai A. ; Rizk, Nehal I. ; Elrebehy, Mahmoud A. ; Zewail, Moataz B. ; Mohammed, Osama A. ; Doghish, Ahmed S.
Assuntos: Diagnosis ; MCC ; Merkel cell carcinoma ; MiRNAs, Biomarker ; Prognosis
É parte de: Pathology, research and practice, 2023-09, Vol.249, p.154763-154763, Article 154763
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Descrição: Merkel cell carcinoma (MCC) is a rare, aggressive form of skin malignancy with a high recurrence commonly within two to three years of initial diagnosis. The incidence of MCC has nearly doubled in the past few decades. Options for diagnosing, assessing, and treating MCC are limited. MicroRNAs (miRNAs) are a class of small, non-coding RNA molecules that play an important role in controlling many different aspects of cell biology. Many miRNAs are aberrantly expressed in distinct types of cancer, with some serving as tumor suppressors and others as oncomiRs. Therefore, the future holds great promise for the utilization of miRNAs in enhancing diagnostic, prognostic, and therapeutic approaches for MCC. Accordingly, the goal of this article is to compile, summarize, and discuss the latest research on miRNAs in MCC, highlighting their potential clinical utility as diagnostic and prognostic biomarkers.
Editor: Elsevier GmbH
Idioma: Inglês

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miRNAs driving diagnosis, prognosis and progression in Merkel cell carcinoma

Elsevier GmbH

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