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Mid-regional proadrenomedullin, C-terminal proendothelin-1 values, and disease course are not different in critically ill SARS-CoV-2 pneumonia patients with obesity

van Oers, Jos A. H. ; Pouwels, Sjaak ; Ramnarain, Dharmanand ; Kluiters, Yvette ; Bons, Judith A. P. ; de Lange, Dylan W. ; de Grooth, Harm-Jan ; Girbes, Armand R. J.

International Journal of Obesity, 2022-10, Vol.46 (10), p.1801-1807 [Periódico revisado por pares]

London: Nature Publishing Group

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  • Título:
    Mid-regional proadrenomedullin, C-terminal proendothelin-1 values, and disease course are not different in critically ill SARS-CoV-2 pneumonia patients with obesity
  • Autor: van Oers, Jos A. H. ; Pouwels, Sjaak ; Ramnarain, Dharmanand ; Kluiters, Yvette ; Bons, Judith A. P. ; de Lange, Dylan W. ; de Grooth, Harm-Jan ; Girbes, Armand R. J.
  • Assuntos: Adrenomedullin ; Biomarkers ; Body mass ; Body mass index ; Body size ; C-reactive protein ; Coronaviruses ; COVID-19 ; Inflammation ; Obesity ; Patients ; Pneumonia ; Procalcitonin ; Respiratory diseases ; Severe acute respiratory syndrome ; Severe acute respiratory syndrome coronavirus 2 ; Viral diseases
  • É parte de: International Journal of Obesity, 2022-10, Vol.46 (10), p.1801-1807
  • Notas: ObjectType-Article-2
    SourceType-Scholarly Journals-1
    ObjectType-Feature-1
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  • Descrição: Background/objectivesPatients affected by obesity and Coronavirus disease 2019, the disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), appear to have a higher risk for intensive care (ICU) admission. A state of low-grade chronic inflammation in obesity has been suggested as one of the underlying mechanisms. We investigated whether obesity is associated with differences in new inflammatory biomarkers mid-regional proadrenomedullin (MR-proADM), C-terminal proendothelin-1 (CT-proET-1), and clinical outcomes in critically ill patients with SARS-CoV-2 pneumonia.Subjects/methodsA total of 105 critically ill patients with SARS-CoV-2 pneumonia were divided in patients with obesity (body mass index (BMI) ≥ 30 kg/m2, n = 42) and patients without obesity (BMI < 30 kg/m2, n = 63) and studied in a retrospective observational cohort study. MR-proADM, CT-proET-1 concentrations, and conventional markers of white blood count (WBC), C-reactive protein (CRP), and procalcitonin (PCT) were collected during the first 7 days.ResultsBMI was 33.5 (32–36.1) and 26.2 (24.7–27.8) kg/m2 in the group with and without obesity. There were no significant differences in concentrations MR-proADM, CT-proET-1, WBC, CRP, and PCT at baseline and the next 6 days between patients with and without obesity. Only MR-proADM changed significantly over time (p = 0.039). Also, BMI did not correlate with inflammatory biomarkers (MR-proADM rho = 0.150, p = 0.125, CT-proET-1 rho = 0.179, p = 0.067, WBC rho = −0.044, p = 0.654, CRP rho = 0.057, p = 0.564, PCT rho = 0.022, p = 0.842). Finally, no significant differences in time on a ventilator, ICU length of stay, and 28-day mortality between patients with or without obesity were observed.ConclusionsIn critically ill patients with confirmed SARS-CoV-2 pneumonia, obesity was not associated with differences in MR-proADM, and CT-proET-1, or impaired outcome.Trial registrationNetherlands Trial Register, NL8460.
  • Editor: London: Nature Publishing Group
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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