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Effects of hypophysectomy and acth administration on trophic response of rat adrenal gland

T. E. P. Torres Claudimara Ferini Pacicco Lotfi; Congress of the Brazilian Society for Cell Biology (12. 2004 Campinas); Ibero-American Congress of Cell Biology (9. 2004 Campinas)

Abstracts Campinas, SP

Campinas 2004

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  • Título:
    Effects of hypophysectomy and acth administration on trophic response of rat adrenal gland
  • Autor: T. E. P. Torres
  • Claudimara Ferini Pacicco Lotfi; Congress of the Brazilian Society for Cell Biology (12. 2004 Campinas); Ibero-American Congress of Cell Biology (9. 2004 Campinas)
  • Assuntos: ANATOMIA
  • É parte de: Abstracts Campinas, SP
  • Notas Locais: Disponível em CD-ROM
  • Descrição: The purpose of this study was to evaluate the effects of hypophysectomy on morphological changes of rat adrenal cortex gland and analyzed the fos, jun and myc protooncogenes families expression in hypophysectomized rats (HP) treated with ACTH (adrenocorticotropin) and/or FGF2 (fibroblast growth factor). A number of studies have demonstrated induction of Fos and Jun protein expression following ACTH and FGF2 treatment of adrenal cells in culture. However, the effect of ACTH and FGF2 on regulation of these protein families in the zones of adrenal cortex (glomerulosa-zG, fasciculata-zF and reticularis-zR) has not been demonstrated in vivo. Furthermore, regulation of these proteins has not been analyzed following alterations in the adrenal tropic state of an animal. Male Sprague Dawley rats were HP according to standard procedures and kept under normal diet. The operation was confirmed by physical inspection of sella turcica. HP received an i.p. injection of either saline, 10-7MACTH or/and 20ng/mlFGF2, 2h prior to harvesting the glands. Animals were killed and the gland harvested, fixed, embedded in paraffin, cut at 5µm. Morphological alterations was measured using HE stain and the protein expression was determined by immunohistochemistry. The atrophic effect of HP was in the inner adrenal cortical zones (zF and zR) and had less effect in zG and was seen within 3 days following HP. HP rats treated with ACTH showed cFos protein expression in zF
  • Editor: Campinas
  • Data de criação/publicação: 2004
  • Formato: [s. p.].
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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