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GPR56/ADGRG1 is associated with response to antidepressant treatment

Belzeaux, Raoul ; Gorgievski, Victor ; Fiori, Laura M ; Lopez, Juan Pablo ; Grenier, Julien ; Lin, Rixing ; Nagy, Corina ; Ibrahim, El Chérif ; Gascon, Eduardo ; Courtet, Philippe ; Richard-Devantoy, Stéphane ; Berlim, Marcelo ; Chachamovich, Eduardo ; Théroux, Jean-François ; Dumas, Sylvie ; Giros, Bruno ; Rotzinger, Susan ; Soares, Claudio N ; Foster, Jane A ; Mechawar, Naguib ; Tall, Gregory G ; Tzavara, Eleni T ; Kennedy, Sidney H ; Turecki, Gustavo

Nature communications, 2020-04, Vol.11 (1), p.1635-1635, Article 1635 [Periódico revisado por pares]

England: Nature Publishing Group

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Título:
GPR56/ADGRG1 is associated with response to antidepressant treatment
Autor: Belzeaux, Raoul ; Gorgievski, Victor ; Fiori, Laura M ; Lopez, Juan Pablo ; Grenier, Julien ; Lin, Rixing ; Nagy, Corina ; Ibrahim, El Chérif ; Gascon, Eduardo ; Courtet, Philippe ; Richard-Devantoy, Stéphane ; Berlim, Marcelo ; Chachamovich, Eduardo ; Théroux, Jean-François ; Dumas, Sylvie ; Giros, Bruno ; Rotzinger, Susan ; Soares, Claudio N ; Foster, Jane A ; Mechawar, Naguib ; Tall, Gregory G ; Tzavara, Eleni T ; Kennedy, Sidney H ; Turecki, Gustavo
Assuntos: Adult ; AKT protein ; Animals ; Antidepressants ; Antidepressive Agents - administration & dosage ; Blood ; Cohort Studies ; Depressive Disorder, Major - drug therapy ; Depressive Disorder, Major - genetics ; Depressive Disorder, Major - metabolism ; Female ; Glycogen Synthase Kinase 3 - metabolism ; Human health and pathology ; Humans ; Life Sciences ; Male ; Mental depression ; Mice ; Mice, Inbred C57BL ; Middle Aged ; mRNA ; Norepinephrine ; Prefrontal cortex ; Prefrontal Cortex - drug effects ; Prefrontal Cortex - metabolism ; Psychiatrics and mental health ; Psychiatrists ; Receptors, G-Protein-Coupled - genetics ; Receptors, G-Protein-Coupled - metabolism ; Serotonin ; Serotonin Uptake Inhibitors - administration & dosage ; Suicide ; Treatment Outcome
É parte de: Nature communications, 2020-04, Vol.11 (1), p.1635-1635, Article 1635
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-News-1
ObjectType-Feature-3
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Descrição: It remains unclear why many patients with depression do not respond to antidepressant treatment. In three cohorts of individuals with depression and treated with serotonin-norepinephrine reuptake inhibitor (N = 424) we show that responders, but not non-responders, display an increase of GPR56 mRNA in the blood. In a small group of subjects we also show that GPR56 is downregulated in the PFC of individuals with depression that died by suicide. In mice, we show that chronic stress-induced Gpr56 downregulation in the blood and prefrontal cortex (PFC), which is accompanied by depression-like behavior, and can be reversed by antidepressant treatment. Gpr56 knockdown in mouse PFC is associated with depressive-like behaviors, executive dysfunction and poor response to antidepressant treatment. GPR56 peptide agonists have antidepressant-like effects and upregulated AKT/GSK3/EIF4 pathways. Our findings uncover a potential role of GPR56 in antidepressant response.
Editor: England: Nature Publishing Group
Idioma: Inglês

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GPR56/ADGRG1 is associated with response to antidepressant treatment

England: Nature Publishing Group

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