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Phenolic compounds with IL-6 inhibitory activity from Aster yomena

Kim, A Ryun ; Jin, Qinglong ; Jin, Hong-Guang ; Ko, Hae Ju ; Woo, Eun-Rhan

Archives of Pharmacal Research, 2014, 37(7), , pp.845-851 [Periódico revisado por pares]

Heidelberg: Pharmaceutical Society of Korea

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Título:
Phenolic compounds with IL-6 inhibitory activity from Aster yomena
Autor: Kim, A Ryun ; Jin, Qinglong ; Jin, Hong-Guang ; Ko, Hae Ju ; Woo, Eun-Rhan
Assuntos: Aster Plant ; Humans ; Interleukin-6 - antagonists & inhibitors ; Interleukin-6 - metabolism ; Medicine ; Pharmacology/Toxicology ; Pharmacy ; Phenols - chemistry ; Phenols - isolation & purification ; Phenols - pharmacology ; Plant Components, Aerial ; Plant Extracts - chemistry ; Plant Extracts - isolation & purification ; Plant Extracts - pharmacology ; Research Article ; 약학
É parte de: Archives of Pharmacal Research, 2014, 37(7), , pp.845-851
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
KISTI1.1003/JNL.JAKO201426955812395
G704-000010.2014.37.7.009
Descrição: A new biflavonoid, named asteryomenin ( 1 ), as well as six known phenolic compounds, esculetin ( 2 ), 4- O -β- d -glucopyranoside-3-hydroxy methyl benzoate ( 3 ), caffeic acid ( 4 ), isoquercitrin ( 5 ), isorhamnetin-3- O -glucoside ( 6 ), and apigenin ( 7 ) were isolated from the aerial parts of Aster yomena . The structures of compounds ( 1–7 ) were identified based on 1D and 2D NMR, including 1 H– 1 H COSY, HSQC, HMBC and NOESY spectroscopic analyses. Compounds 2–7 were isolated from this plant for the first time. For these isolates, the inhibitory activity of IL-6 production in the TNF-α stimulated MG-63 cell was examined. Among these isolates, compounds 4 and 7 appeared to have potent inhibitory activity of IL-6 production in the TNF-α stimulated MG-63 cell, while compounds 1–3 and 5–6 showed moderate activity.
Editor: Heidelberg: Pharmaceutical Society of Korea
Idioma: Inglês;Coreano

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Phenolic compounds with IL-6 inhibitory activity from Aster yomena

Kim, A Ryun ; Jin, Qinglong ; Jin, Hong-Guang ; Ko, Hae Ju ; Woo, Eun-Rhan

Heidelberg: Pharmaceutical Society of Korea

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