Idioma:

Anxiolytic-like effects of substance P administration into the dorsal, but not ventral, hippocampus and its influence on serotonin

Carvalho, M.C. ; Masson, S. ; Brandão, M.L. ; de Souza Silva, M.A.

Peptides (New York, N.Y. : 1980), 2008-07, Vol.29 (7), p.1191-1200 [Periódico revisado por pares]

New York, NY: Elsevier Inc

Texto completo disponível

Citações Citado por

Enviar para

Título:
Anxiolytic-like effects of substance P administration into the dorsal, but not ventral, hippocampus and its influence on serotonin
Autor: Carvalho, M.C. ; Masson, S. ; Brandão, M.L. ; de Souza Silva, M.A.
Assuntos: Animals ; Anti-Anxiety Agents - pharmacology ; Anxiety ; Anxiety - chemically induced ; Anxiety - drug therapy ; Biological and medical sciences ; Dorsal hippocampus ; Dose-Response Relationship, Drug ; Elevated plus-maze ; Fundamental and applied biological sciences. Psychology ; Hippocampus - drug effects ; Injections, Intraventricular ; Male ; Maze Learning - drug effects ; Maze Learning - physiology ; Medical sciences ; Microdialysis - methods ; Microinjections ; Neuropharmacology ; Pharmacology. Drug treatments ; Psycholeptics: tranquillizer, neuroleptic ; Psychology. Psychoanalysis. Psychiatry ; Psychopharmacology ; Rat ; Rats ; Rats, Wistar ; Serotonin - analysis ; Serotonin - metabolism ; Substance P ; Substance P - administration & dosage ; Ventral hippocampus ; Vertebrates: endocrinology
É parte de: Peptides (New York, N.Y. : 1980), 2008-07, Vol.29 (7), p.1191-1200
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Substance P (SP) is known to be involved in processes related to learning and memory, fear, anxiety and stress. SP and NK1 receptors are localized in the hippocampus, a brain structure involved in learning and memory as well as emotional processes. As there is evidence for differential functions of the ventral (VH) and dorsal (DH) hippocampus in a variety of behaviors, we here evaluated the effects of injections of SP into the VH and DH in rats submitted to the elevated plus-maze (EPM) and open field (OF) tests. The results obtained showed that infusions of 100 and 1000 ng of SP into the DH, but not VH, increased open arm activity in the EPM and in the central zone of the OF, indicative of anxiolytic-like action. These effects were observed in the absence of significant changes in general motor activity. In an additional experiment to examine whether these effects of SP are mediated by local serotoninergic mechanisms, extracellular concentrations of this monoamine were assessed by use of in vivo microdialysis. Infusions of SP into the DH did not influence the extracellular concentration of serotonin. These data indicate that neurokinins in the DH, but not VH, are involved in mechanisms associated with anxiety and that the mediation of SP in anxiety-related behaviors is independent of local serotonergic mechanisms.
Editor: New York, NY: Elsevier Inc
Idioma: Inglês

Links

Voltar para lista de resultados

Anterior Resultado 9 Avançar Ir para próxima página

Realização: Logos de Redes Sociais:

Anxiolytic-like effects of substance P administration into the dorsal, but not ventral, hippocampus and its influence on serotonin

Carvalho, M.C. ; Masson, S. ; Brandão, M.L. ; de Souza Silva, M.A.

New York, NY: Elsevier Inc

Buscando em bases de dados remotas. Favor aguardar.