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Endogenous adenosine down-modulates mid-trimester intraamniotic tumor necrosis factor-alpha production

Perni, Uma ; Sezen, Devrim ; Bongiovanni, Ann Marie ; Linhares, Iara M ; Skupski, Daniel ; Witkin, Steven S

American journal of reproductive immunology (1989), 2009-10, Vol.62 (4), p.232-237 [Periódico revisado por pares]

Denmark

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Título:
Endogenous adenosine down-modulates mid-trimester intraamniotic tumor necrosis factor-alpha production
Autor: Perni, Uma ; Sezen, Devrim ; Bongiovanni, Ann Marie ; Linhares, Iara M ; Skupski, Daniel ; Witkin, Steven S
Assuntos: Adenosine - immunology ; Adenosine - metabolism ; Adult ; Amniocentesis ; Amniotic Fluid - immunology ; Amniotic Fluid - metabolism ; AMP Deaminase - metabolism ; Down-Regulation ; Female ; Gene Expression Regulation ; Gestational Age ; Humans ; Interleukin-10 - secretion ; Interleukin-6 - secretion ; Maternal Age ; Pregnancy ; Pregnancy Trimester, Second - metabolism ; Tumor Necrosis Factor-alpha - genetics ; Tumor Necrosis Factor-alpha - immunology ; Tumor Necrosis Factor-alpha - metabolism
É parte de: American journal of reproductive immunology (1989), 2009-10, Vol.62 (4), p.232-237
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: To determine whether adenosine in amniotic fluid down-regulates pro-inflammatory cytokine production. Mid-trimester amniotic fluid from 21 women was incubated ex vivo in the presence or absence of human adenosine deaminase, the enzyme that irreversibly degrades adenosine. After 24 hr, supernatants were assayed by ELISA for tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-6, and IL-10. Clinical parameters were obtained after completion of laboratory testing. Inclusion of adenosine deaminase resulted in a median increase in TNF-alpha production from 0.9 to 7.3 pg/mL (P = 0.0014). IL-6 production exhibited a non-significant median increase from <2.0 to 53.0 pg/mL (P = 0.0780). Median IL-10 production increased slightly from a median of <0.2 to 1.3 pg/mL. Adenosine deaminase-stimulated TNF-alpha production was proportional to parity and unrelated to gestational age, time of delivery, maternal age or indication for amniocentesis. Adenosine deaminase treatment increases TNF-alpha production by ex vivo-cultured amniotic fluid. Adenosine contributes to immune modulation in the amniotic cavity.
Editor: Denmark
Idioma: Inglês

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Endogenous adenosine down-modulates mid-trimester intraamniotic tumor necrosis factor-alpha production

Perni, Uma ; Sezen, Devrim ; Bongiovanni, Ann Marie ; Linhares, Iara M ; Skupski, Daniel ; Witkin, Steven S

Denmark

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