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Effects of acute administration of donepezil or memantine on sleep-deprivation-induced spatial memory deficit in young and aged non-human primate grey mouse lemurs (Microcebus murinus)

Rahman, Anisur ; Lamberty, Yves ; Schenker, Esther ; Cella, Massimo ; Languille, Solène ; Bordet, Régis ; Richardson, Jill ; Pifferi, Fabien ; Aujard, Fabienne Ginsberg, Stephen D

PloS one, 2017-09, Vol.12 (9), p.e0184822-e0184822 [Periódico revisado por pares]

United States: Public Library of Science

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Título:
Effects of acute administration of donepezil or memantine on sleep-deprivation-induced spatial memory deficit in young and aged non-human primate grey mouse lemurs (Microcebus murinus)
Autor: Rahman, Anisur ; Lamberty, Yves ; Schenker, Esther ; Cella, Massimo ; Languille, Solène ; Bordet, Régis ; Richardson, Jill ; Pifferi, Fabien ; Aujard, Fabienne
Ginsberg, Stephen D
Assuntos: Acetylcholinesterase ; Aging ; Aging (artificial) ; Aging - drug effects ; Alzheimer Disease - complications ; Alzheimer Disease - drug therapy ; Alzheimer Disease - physiopathology ; Alzheimer's disease ; Analysis ; Animal cognition ; Animal models ; Animals ; Biology and Life Sciences ; Brain ; Cheirogaleidae ; Cognitive ability ; Complications and side effects ; Dementia ; Disease Models, Animal ; Donepezil ; Dosage and administration ; Drug development ; Drug therapy ; Drugs ; Glutamic acid receptors ; Health aspects ; Impairment ; Indans - pharmacology ; Lemurs ; Life Sciences ; Male ; Medicine and Health Sciences ; Memantine ; Memantine - pharmacology ; Memory ; Memory disorders ; Memory Disorders - drug therapy ; Memory Disorders - etiology ; Memory Disorders - physiopathology ; Memory tasks ; Memory, Disorders of ; Monkeys & apes ; N-Methyl-D-aspartic acid receptors ; Neurodegenerative diseases ; Neurons and Cognition ; Pharmacology ; Phylogeny ; Piperidines - pharmacology ; Primates ; Psychological aspects ; Research and Analysis Methods ; Risk factors ; Rodents ; Sleep ; Sleep deprivation ; Sleep Deprivation - complications ; Sleep Deprivation - drug therapy ; Sleep Deprivation - physiopathology ; Spatial analysis ; Spatial memory ; Spatial Memory - drug effects ; Studies ; Translation ; Visual task performance
É parte de: PloS one, 2017-09, Vol.12 (9), p.e0184822-e0184822
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
PMCID: PMC5602634
Competing Interests: YL salary was supported by UCB Pharma s.a., Neuroscience Therapeutic Area, Braine l'Alleud, Belgium, JR salary was supported by GlaxoSmithKline, Neurosciences Therapeutic Unit, Gunnels Wood Road, Stevenage, Herts., UK' and MC salary was supported by Chiesi Farmaceutici, Department of Clinical Pharmacology, Global Clinical Development, Parma, Italy. These affiliations do not alter our adherence to PLOS ONE policies on sharing data and materials.
Descrição: The development of novel therapeutics to prevent cognitive decline of Alzheimer's disease (AD) is facing paramount difficulties since the translational efficacy of rodent models did not resulted in better clinical results. Currently approved treatments, including the acetylcholinesterase inhibitor donepezil (DON) and the N-methyl-D-aspartate antagonist memantine (MEM) provide marginal therapeutic benefits to AD patients. There is an urgent need to develop a predictive animal model that is phylogenetically proximal to humans to achieve better translation. The non-human primate grey mouse lemur (Microcebus murinus) is increasingly used in aging research, but there is no published results related to the impact of known pharmacological treatments on age-related cognitive impairment observed in this primate. In the present study we investigated the effects of DON and MEM on sleep-deprivation (SD)-induced memory impairment in young and aged male mouse lemurs. In particular, spatial memory impairment was evaluated using a circular platform task after 8 h of total SD. Acute single doses of DON or MEM (0.1 and 1mg/kg) or vehicle were administered intraperitoneally 3 h before the cognitive task during the SD procedure. Results indicated that both doses of DON were able to prevent the SD-induced deficits in retrieval of spatial memory as compared to vehicle-treated animals, both in young and aged animals Likewise, MEM show a similar profile at 1 mg/kg but not at 0.1mg/kg. Taken together, these results indicate that two widely used drugs for mitigating cognitive deficits in AD were partially effective in sleep deprived mouse lemurs, which further support the translational potential of this animal model. Our findings demonstrate the utility of this primate model for further testing cognitive enhancing drugs in development for AD or other neuropsychiatric conditions.
Editor: United States: Public Library of Science
Idioma: Inglês

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Effects of acute administration of donepezil or memantine on sleep-deprivation-induced spatial memory deficit in young and aged non-human primate grey mouse lemurs (Microcebus murinus)

Rahman, Anisur ; Lamberty, Yves ; Schenker, Esther ; Cella, Massimo ; Languille, Solène ; Bordet, Régis ; Richardson, Jill ; Pifferi, Fabien ; Aujard, Fabienne Ginsberg, Stephen D

United States: Public Library of Science

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