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Adipokines: The missing link between insulin resistance and obesity

Antuna-Puente, B ; Feve, B ; Fellahi, S ; Bastard, J.-P

Diabetes & metabolism, 2008-02, Vol.34 (1), p.2-11 [Periódico revisado por pares]

Paris: Elsevier Masson SAS

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Título:
Adipokines: The missing link between insulin resistance and obesity
Autor: Antuna-Puente, B ; Feve, B ; Fellahi, S ; Bastard, J.-P
Assuntos: Adipocyte ; Adipokines ; Adipokines - physiology ; Adiponectin - physiology ; Biological and medical sciences ; Diabetes ; Diabetes. Impaired glucose tolerance ; Diabète ; Endocrine pancreas. Apud cells (diseases) ; Endocrinology & Metabolism ; Endocrinopathies ; Endoplasmic Reticulum - physiology ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Humans ; Inflammation - physiopathology ; Insulin Resistance - physiology ; Interleukin-6 - physiology ; Internal Medicine ; Leptin - physiology ; Macrophage ; Medical sciences ; Metabolic diseases ; Metabolic syndrome ; Miscellaneous ; Nicotinamide Phosphoribosyltransferase - physiology ; Obesity ; Obesity - physiopathology ; Obésité ; Other metabolic disorders ; Plasminogen Activator Inhibitor 1 - physiology ; Resistin - physiology ; Review ; Revue générale ; Serum Amyloid A Protein - physiology ; Syndrome métabolique ; Tissu adipeux viscéral ; Tumor Necrosis Factor-alpha - physiology ; Visceral adipose tissue
É parte de: Diabetes & metabolism, 2008-02, Vol.34 (1), p.2-11
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
Descrição: Abstract White adipose tissue was believed to be just an energy-storage organ, but it is now recognized to be an active participant in energy homoeostasis and physiological functions such as immunity and inflammation. Macrophages are components of adipose tissue and actively participate in its activities. Adipose tissue is known to express and secrete a variety of products known as ‘adipokines’, including leptin, adiponectin, resistin and visfatin, as well as cytokines and chemokines such as tumor necrosis factor-alpha, interleukin-6 and monocyte chemoattractant protein-1. The release of adipokines by either adipocytes or adipose tissue-infiltrated macrophages leads to a chronic subinflammatory state that could play a central role in the development of insulin resistance and type 2 diabetes, and the increased risk of cardiovascular disease associated with obesity.
Editor: Paris: Elsevier Masson SAS
Idioma: Inglês

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Adipokines: The missing link between insulin resistance and obesity

Antuna-Puente, B ; Feve, B ; Fellahi, S ; Bastard, J.-P

Paris: Elsevier Masson SAS

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