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CAR-NK cells: A promising cellular immunotherapy for cancer

Xie, Guozhu ; Dong, Han ; Liang, Yong ; Ham, James Dongjoo ; Rizwan, Romee ; Chen, Jianzhu

EBioMedicine, 2020-09, Vol.59, p.102975, Article 102975 [Periódico revisado por pares]

Netherlands: Elsevier B.V

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  • Título:
    CAR-NK cells: A promising cellular immunotherapy for cancer
  • Autor: Xie, Guozhu ; Dong, Han ; Liang, Yong ; Ham, James Dongjoo ; Rizwan, Romee ; Chen, Jianzhu
  • Assuntos: Cancer ; Chimeric antigen receptor ; Immunotherapy ; NK cells ; Review
  • É parte de: EBioMedicine, 2020-09, Vol.59, p.102975, Article 102975
  • Descrição: Natural Killer (NK) cells and CD8+ cytotoxic T cells are two types of immune cells that can kill target cells through similar cytotoxic mechanisms. With the remarkable success of chimeric antigen receptor (CAR)-engineered T (CAR-T) cells for treating haematological malignancies, there is a rapid growing interest in developing CAR-engineered NK (CAR-NK) cells for cancer therapy. Compared to CAR-T cells, CAR-NK cells could offer some significant advantages, including: (1) better safety, such as a lack or minimal cytokine release syndrome and neurotoxicity in autologous setting and graft-versus-host disease in allogenic setting, (2) multiple mechanisms for activating cytotoxic activity, and (3) high feasibility for ‘off-the-shelf’ manufacturing. CAR-NK cells could be engineered to target diverse antigens, enhance proliferation and persistence in vivo, increase infiltration into solid tumours, overcome resistant tumour microenvironment, and ultimately achieve an effective anti-tumour response. In this review, we focus on recent progress in genetic engineering and clinical application of CAR-NK cells, and discuss current challenges and future promise of CAR-NK cells as a novel cellular immunotherapy in cancer.
  • Editor: Netherlands: Elsevier B.V
  • Idioma: Inglês
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