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Long term exposure to air pollution and kidney parenchyma cancer – Effects of low-level air pollution: a Study in Europe (ELAPSE)

Hvidtfeldt, Ulla Arthur ; Taj, Tahir ; Chen, Jie ; Rodopoulou, Sophia ; Strak, Maciej ; de Hoogh, Kees ; Andersen, Zorana J. ; Bellander, Tom ; Brandt, Jørgen ; Fecht, Daniela ; Forastiere, Francesco ; Gulliver, John ; Hertel, Ole ; Hoffmann, Barbara ; Jørgensen, Jeanette T. ; Katsouyanni, Klea ; Ketzel, Matthias ; Lager, Anton ; Leander, Karin ; Ljungman, Petter ; Magnusson, Patrik K.E. ; Nagel, Gabriele ; Pershagen, Göran ; Rizzuto, Debora ; Samoli, Evangelia ; So, Rina ; Stafoggia, Massimo ; Tjønneland, Anne ; Vermeulen, Roel ; Weinmayr, Gudrun ; Wolf, Kathrin ; Zhang, Jiawei ; Zitt, Emanuel ; Brunekreef, Bert ; Hoek, Gerard ; Raaschou-Nielsen, Ole

Environmental research, 2022-12, Vol.215 (Pt 2), p.114385, Article 114385 [Periódico revisado por pares]

Netherlands: Elsevier Inc

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Título:
Long term exposure to air pollution and kidney parenchyma cancer – Effects of low-level air pollution: a Study in Europe (ELAPSE)
Autor: Hvidtfeldt, Ulla Arthur ; Taj, Tahir ; Chen, Jie ; Rodopoulou, Sophia ; Strak, Maciej ; de Hoogh, Kees ; Andersen, Zorana J. ; Bellander, Tom ; Brandt, Jørgen ; Fecht, Daniela ; Forastiere, Francesco ; Gulliver, John ; Hertel, Ole ; Hoffmann, Barbara ; Jørgensen, Jeanette T. ; Katsouyanni, Klea ; Ketzel, Matthias ; Lager, Anton ; Leander, Karin ; Ljungman, Petter ; Magnusson, Patrik K.E. ; Nagel, Gabriele ; Pershagen, Göran ; Rizzuto, Debora ; Samoli, Evangelia ; So, Rina ; Stafoggia, Massimo ; Tjønneland, Anne ; Vermeulen, Roel ; Weinmayr, Gudrun ; Wolf, Kathrin ; Zhang, Jiawei ; Zitt, Emanuel ; Brunekreef, Bert ; Hoek, Gerard ; Raaschou-Nielsen, Ole
Assuntos: adult ; adverse event ; air pollutant ; Air Pollutants ; Air Pollutants - analysis ; Air Pollutants - toxicity ; air Pollution ; Air Pollution - adverse effects ; Air Pollution - analysis ; ambient air ; analysis ; atmospheric pollution ; black carbon ; body mass ; cancer ; cancer incidence ; cancer registry ; carbon ; Carbon - analysis ; carcinogen ; Carcinogens ; Carcinogens - analysis ; cohort analysis ; confidence interval ; controlled study ; copper ; Copper - analysis ; DNA ; environmental exposure ; Environmental Exposure - adverse effects ; Environmental Exposure - analysis ; Europe ; Europe - epidemiology ; European ; exhaust gas ; female ; follow up ; human ; Humans ; ICD-9 ; iron ; Iron - analysis ; Kidney ; kidney cancer ; Kidney cancer incidence ; Kidney Neoplasms ; Kidney Neoplasms - chemically induced ; Kidney Neoplasms - epidemiology ; kidney parenchyma ; kidney tumor ; long term exposure ; major clinical study ; male ; Medicin och hälsovetenskap ; Nickel ; Nitrogen dioxide ; Nitrogen Dioxide - analysis ; Nitrogen Dioxide - toxicity ; obesity ; Ozone ; Ozone - analysis ; Particulate matter ; Particulate Matter - analysis ; Particulate Matter - toxicity ; PM elemental Components ; PM2.5 exposure ; pollution exposure ; potassium ; Potassium - analysis ; proportional hazards model ; residential area ; season ; Silicon ; soot ; Soot - analysis ; sulfur ; Sulfur - analysis ; toxicity ; trace metal ; Vanadium ; Vehicle Emissions ; Vehicle Emissions - analysis ; zinc ; Zinc - analysis
É parte de: Environmental research, 2022-12, Vol.215 (Pt 2), p.114385, Article 114385
Descrição: Background: Particulate matter (PM) is classified as a group 1 human carcinogen. Previous experimental studies suggest that particles in diesel exhaust induce oxidative stress, inflammation and DNA damage in kidney cells, but the evidence from population studies linking air pollution to kidney cancer is limited. Methods: We pooled six European cohorts (N = 302,493) to assess the association of residential exposure to fine particles (PM2.5), nitrogen dioxide (NO2), black carbon (BC), warm season ozone (O3) and eight elemental components of PM2.5 (copper, iron, potassium, nickel, sulfur, silicon, vanadium, and zinc) with cancer of the kidney parenchyma. The main exposure model was developed for year 2010. We defined kidney parenchyma cancer according to the International Classification of Diseases 9th and 10th Revision codes 189.0 and C64. We applied Cox proportional hazards models adjusting for potential confounders at the individual and area-level. Results: The participants were followed from baseline (1985–2005) to 2011–2015. A total of 847 cases occurred during 5,497,514 person-years of follow-up (average 18.2 years). Median (5–95%) exposure levels of NO2, PM2.5, BC and O3 were 24.1 μg/m3 (12.8–39.2), 15.3 μg/m3 (8.6–19.2), 1.6 10−5 m−1 (0.7–2.1), and 87.0 μg/m3 (70.3–97.4), respectively. The results of the fully adjusted linear analyses showed a hazard ratio (HR) of 1.03 (95% confidence interval [CI]: 0.92, 1.15) per 10 μg/m³ NO2, 1.04 (95% CI: 0.88, 1.21) per 5 μg/m³ PM2.5, 0.99 (95% CI: 0.89, 1.11) per 0.5 10−5 m−1 BCE, and 0.88 (95% CI: 0.76, 1.02) per 10 μg/m³ O3. We did not find associations between any of the elemental components of PM2.5 and cancer of the kidney parenchyma. Conclusion: We did not observe an association between long-term ambient air pollution exposure and incidence of kidney parenchyma cancer. •A large sample size was obtained by pooling six cohorts with harmonized covariates.•A newly developed Europe-wide spatial land-use regression model was applied.•Results did not indicate a role of air pollutants in development of kidney cancer.
Editor: Netherlands: Elsevier Inc
Idioma: Inglês

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Long term exposure to air pollution and kidney parenchyma cancer – Effects of low-level air pollution: a Study in Europe (ELAPSE)

Netherlands: Elsevier Inc

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