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Targeting epigenetics for cancer therapy
Park, Jong Woo ; Han, Jeung-Whan
Archives of Pharmacal Research, 2019, 42(2), , pp.159-170
[Periódico revisado por pares]
Seoul: Pharmaceutical Society of Korea
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Título:
Targeting epigenetics for cancer therapy
Autor:
Park, Jong Woo
;
Han, Jeung-Whan
Assuntos:
Medicine
;
Pharmacology/Toxicology
;
Pharmacy
;
Review
;
약학
É parte de:
Archives of Pharmacal Research, 2019, 42(2), , pp.159-170
Notas:
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
https://doi.org/10.1007/s12272-019-01126-z
Descrição:
Cancer can be identified as a chaotic cell state, which breaks the rules that govern growth and reproduction, with main characteristics such as uncontrolled division, invading other tissues, usurping resources, and eventually killing its host. It was once believed that cancer is caused by a progressive series of genetic aberrations, and certain mutations of genes, including oncogenes and tumor suppressor genes, have been identified as the cause of cancer. However, piling evidence suggests that epigenetic modifications working in concert with genetic mechanisms to regulate transcriptional activity are dysregulated in many diseases, including cancer. Cancer epigenetics explain a wide range of heritable changes in gene expression, which do not come from any alteration in DNA sequences. Aberrant DNA methylation, histone modifications, and expression of long non-coding RNAs (lncRNAs) are key epigenetic mechanisms associated with tumor initiation, cancer progression, and metastasis. Within the past decade, cancer epigenetics have enabled us to develop novel biomarkers and therapeutic target for many types of cancers. In this review, we will summarize the major epigenetic changes involved in cancer biology along with clinical and preclinical results developed as novel cancer therapeutics.
Editor:
Seoul: Pharmaceutical Society of Korea
Idioma:
Inglês
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