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Influence of epigenetic in Sjögren's syndrome

Bordron, A ; Charras, A ; Le Dantec, C ; Renaudineau, Y

La revue de medecine interne, 2018-05, Vol.39 (5), p.346-351 [Periódico revisado por pares]

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Título:
Influence of epigenetic in Sjögren's syndrome
Autor: Bordron, A ; Charras, A ; Le Dantec, C ; Renaudineau, Y
Assuntos: B-Lymphocytes - immunology ; Epigenomics - methods ; Epithelial Cells - immunology ; Genetic Predisposition to Disease ; Humans ; Sjogren's Syndrome - genetics ; Sjogren's Syndrome - physiopathology
É parte de: La revue de medecine interne, 2018-05, Vol.39 (5), p.346-351
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Sjögren's syndrome (SS) is a systemic autoimmune epithelitis with a major female incidence, and characterized by a dry syndrome, impaired quality of life, visceral involvement, and lymphoma for the most aggressive cases. During this process, epithelial cells acquire the capacity to produce cytokines, chemokines, and autoantigens which can in turn be presented to the immune system. Consequently, this epithelitis is accompanied by lymphocytic infiltrations leading to the formation of pseudo-follicles in which self-reactive B lymphocytes are present. The recent integration of genomic and especially of epigenomic data, which make it possible to analyze the different cellular partners, opens new perspectives and allows to a better understanding of this complex and still incurable disease.
Editor: France
Idioma: Francês

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