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The Glymphatic System: A Beginner’s Guide

Jessen, Nadia Aalling ; Munk, Anne Sofie Finmann ; Lundgaard, Iben ; Nedergaard, Maiken

Neurochemical research, 2015-12, Vol.40 (12), p.2583-2599 [Periódico revisado por pares]

New York: Springer US

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Título:
The Glymphatic System: A Beginner’s Guide
Autor: Jessen, Nadia Aalling ; Munk, Anne Sofie Finmann ; Lundgaard, Iben ; Nedergaard, Maiken
Assuntos: Aging - cerebrospinal fluid ; Animals ; Astrocytes - metabolism ; Biochemistry ; Biomedical and Life Sciences ; Biomedicine ; Brain Injuries - cerebrospinal fluid ; Cell Biology ; Cerebrospinal Fluid - metabolism ; Cerebrospinal Fluid - physiology ; Humans ; Lymphatic System - metabolism ; Neurochemistry ; Neurology ; Neurosciences ; Original Paper
É parte de: Neurochemical research, 2015-12, Vol.40 (12), p.2583-2599
Notas: These authors contributed equally to the work.
Descrição: The glymphatic system is a recently discovered macroscopic waste clearance system that utilizes a unique system of perivascular tunnels, formed by astroglial cells, to promote efficient elimination of soluble proteins and metabolites from the central nervous system. Besides waste elimination, the glymphatic system also facilitates brain-wide distribution of several compounds, including glucose, lipids, amino acids, growth factors, and neuromodulators. Intriguingly, the glymphatic system function mainly during sleep and is largely disengaged during wakefulness. The biological need for sleep across all species may therefore reflect that the brain must enter a state of activity that enables elimination of potentially neurotoxic waste products, including β-amyloid. Since the concept of the glymphatic system is relatively new, we will here review its basic structural elements, organization, regulation, and functions. We will also discuss recent studies indicating that glymphatic function is suppressed in various diseases and that failure of glymphatic function in turn might contribute to pathology in neurodegenerative disorders, traumatic brain injury and stroke.
Editor: New York: Springer US
Idioma: Inglês

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The Glymphatic System: A Beginner’s Guide

Jessen, Nadia Aalling ; Munk, Anne Sofie Finmann ; Lundgaard, Iben ; Nedergaard, Maiken

New York: Springer US

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