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Cytokine Production in Arthritis Susceptible and Resistant Rats: A Study with Arthritogenic and Non‐arthritogenic Lactobacillus Cell Walls

Šimelyte, E. ; Isomäki, P. ; Rimpiläinen, M. ; Zhang, X. ; Toivanen, P.

Scandinavian journal of immunology, 2001-02, Vol.53 (2), p.132-138 [Periódico revisado por pares]

Oxford, UK: Blackwell Science Ltd

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Título:
Cytokine Production in Arthritis Susceptible and Resistant Rats: A Study with Arthritogenic and Non‐arthritogenic Lactobacillus Cell Walls
Autor: Šimelyte, E. ; Isomäki, P. ; Rimpiläinen, M. ; Zhang, X. ; Toivanen, P.
Assuntos: Animals ; Arthritis, Rheumatoid - genetics ; Arthritis, Rheumatoid - metabolism ; Cell Wall - immunology ; Cytokines - biosynthesis ; Cytokines - blood ; Cytokines - genetics ; Cytokines - physiology ; Disease Models, Animal ; Female ; Genetic Predisposition to Disease ; Injections, Intraperitoneal ; Interleukin-1 - biosynthesis ; Interleukin-1 - blood ; Interleukin-1 - genetics ; Interleukin-1 - physiology ; Interleukin-10 - biosynthesis ; Interleukin-10 - blood ; Interleukin-10 - genetics ; Interleukin-10 - physiology ; Lactobacillus ; Lactobacillus casei - immunology ; Macrophages, Peritoneal - metabolism ; Rats ; Rats, Inbred F344 ; Rats, Inbred Lew ; Species Specificity ; Specific Pathogen-Free Organisms ; Tumor Necrosis Factor-alpha - analysis ; Tumor Necrosis Factor-alpha - biosynthesis ; Tumor Necrosis Factor-alpha - genetics ; Tumor Necrosis Factor-alpha - physiology
É parte de: Scandinavian journal of immunology, 2001-02, Vol.53 (2), p.132-138
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Descrição: The basis of the different susceptibility to bacterial cell wall‐induced arthritis between Lewis and Fischer rats is unclear. Likewise, it is not known why cell walls of some species of Lactobacillus are arthritogenic and those of others are not. With these two questions in mind, we investigated the role of anti‐inflammatory (interleukin (IL)‐10, IL‐4) and proinflammatory (tumour necrosis factor (TNF)‐α, IL‐1β) cytokines in Lewis and Fischer rats injected intraperitoneally with cell walls from arthritogenic or nonarthritogenic species of Lactobacillus. Cytokine levels in the serum and in vitro production by peritoneal macrophages and splenocytes were studied. The results obtained indicate that the differences in the production of IL‐10, IL‐4, TNF‐α or IL‐1β do not explain the difference in the arthritis susceptibility between Lewis and Fischer rats. Likewise, the arthritogenicity of different Lactobacillus cell walls appears not to be dependent on their capacity to stimulate cytokine production.
Editor: Oxford, UK: Blackwell Science Ltd
Idioma: Inglês

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Cytokine Production in Arthritis Susceptible and Resistant Rats: A Study with Arthritogenic and Non‐arthritogenic Lactobacillus Cell Walls

Šimelyte, E. ; Isomäki, P. ; Rimpiläinen, M. ; Zhang, X. ; Toivanen, P.

Oxford, UK: Blackwell Science Ltd

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