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Re-evaluation of putative rheumatoid arthritis susceptibility genes in the post-genome wide association study era and hypothesis of a key pathway underlying susceptibility

Barton, Anne ; Thomson, Wendy ; Ke, Xiayi ; Eyre, Steve ; Hinks, Anne ; Bowes, John ; Gibbons, Laura ; Plant, Darren ; Wilson, Anthony G. ; Marinou, Ioanna ; Morgan, Ann ; Emery, Paul ; Steer, Sophia ; Hocking, Lynne ; Reid, David M. ; Wordsworth, Paul ; Harrison, Pille ; Worthington, Jane

Human molecular genetics, 2008-08, Vol.17 (15), p.2274-2279 [Periódico revisado por pares]

Oxford: Oxford University Press

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Título:
Re-evaluation of putative rheumatoid arthritis susceptibility genes in the post-genome wide association study era and hypothesis of a key pathway underlying susceptibility
Autor: Barton, Anne ; Thomson, Wendy ; Ke, Xiayi ; Eyre, Steve ; Hinks, Anne ; Bowes, John ; Gibbons, Laura ; Plant, Darren ; Wilson, Anthony G. ; Marinou, Ioanna ; Morgan, Ann ; Emery, Paul ; Steer, Sophia ; Hocking, Lynne ; Reid, David M. ; Wordsworth, Paul ; Harrison, Pille ; Worthington, Jane
Assuntos: Antibodies - blood ; Arthritis, Rheumatoid - genetics ; Arthritis, Rheumatoid - immunology ; Biological and medical sciences ; Chromosome Mapping ; Cohort Studies ; Diseases of the osteoarticular system ; Fundamental and applied biological sciences. Psychology ; Genetic Predisposition to Disease ; Genetics of eukaryotes. Biological and molecular evolution ; Genome, Human ; Humans ; Inflammatory joint diseases ; Medical sciences ; Molecular and cellular biology ; Peptides, Cyclic - immunology ; Polymorphism, Single Nucleotide ; STAT4 Transcription Factor - genetics ; TNF Receptor-Associated Factor 1 - genetics
É parte de: Human molecular genetics, 2008-08, Vol.17 (15), p.2274-2279
Notas: ark:/67375/HXZ-FCHXH2V9-H
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Descrição: Rheumatoid arthritis (RA) is an archetypal, common, complex autoimmune disease with both genetic and environmental contributions to disease aetiology. Two novel RA susceptibility loci have been reported from recent genome-wide and candidate gene association studies. We, therefore, investigated the evidence for association of the STAT4 and TRAF1/C5 loci with RA using imputed data from the Wellcome Trust Case Control Consortium (WTCCC). No evidence for association of variants mapping to the TRAF1/C5 gene was detected in the 1860 RA cases and 2930 control samples tested in that study. Variants mapping to the STAT4 gene did show evidence for association (rs7574865, P = 0.04). Given the association of the TRAF1/C5 locus in two previous large case–control series from populations of European descent and the evidence for association of the STAT4 locus in the WTCCC study, single nucleotide polymorphisms mapping to these loci were tested for association with RA in an independent UK series comprising DNA from >3000 cases with disease and >3000 controls and a combined analysis including the WTCCC data was undertaken. We confirm association of the STAT4 and the TRAF1/C5 loci with RA bringing to 5 the number of confirmed susceptibility loci. The effect sizes are less than those reported previously but are likely to be a more accurate reflection of the true effect size given the larger size of the cohort investigated in the current study.
Editor: Oxford: Oxford University Press
Idioma: Inglês

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Re-evaluation of putative rheumatoid arthritis susceptibility genes in the post-genome wide association study era and hypothesis of a key pathway underlying susceptibility

Barton, Anne ; Thomson, Wendy ; Ke, Xiayi ; Eyre, Steve ; Hinks, Anne ; Bowes, John ; Gibbons, Laura ; Plant, Darren ; Wilson, Anthony G. ; Marinou, Ioanna ; Morgan, Ann ; Emery, Paul ; Steer, Sophia ; Hocking, Lynne ; Reid, David M. ; Wordsworth, Paul ; Harrison, Pille ; Worthington, Jane

Oxford: Oxford University Press

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