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Profiling and analysis of multiple constituents in Baizhu Shaoyao San before and after processing by stir-frying using UHPLC/Q-TOF-MS/MS coupled with multivariate statistical analysis

Xu, Yangyang ; Cai, Hao ; Cao, Gang ; Duan, Yu ; Pei, Ke ; Tu, Sicong ; Zhou, Jia ; Xie, Li ; Sun, Dongdong ; Zhao, Jiayu ; Liu, Jing ; Wang, Xiaoqi ; Shen, Lin

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2018-04, Vol.1083, p.110-123 [Periódico revisado por pares]

Netherlands: Elsevier B.V

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Título:
Profiling and analysis of multiple constituents in Baizhu Shaoyao San before and after processing by stir-frying using UHPLC/Q-TOF-MS/MS coupled with multivariate statistical analysis
Autor: Xu, Yangyang ; Cai, Hao ; Cao, Gang ; Duan, Yu ; Pei, Ke ; Tu, Sicong ; Zhou, Jia ; Xie, Li ; Sun, Dongdong ; Zhao, Jiayu ; Liu, Jing ; Wang, Xiaoqi ; Shen, Lin
Assuntos: Baizhu Shaoyao San ; Benzopyrans - analysis ; Benzopyrans - chemistry ; Chemical markers ; Chromatography, High Pressure Liquid - methods ; Cooking - methods ; Drugs, Chinese Herbal - analysis ; Drugs, Chinese Herbal - chemistry ; Flavonoids - analysis ; Flavonoids - chemistry ; Glycosides - analysis ; Glycosides - chemistry ; Lactones - analysis ; Lactones - chemistry ; Multivariate Analysis ; Multivariate statistical analysis ; Tandem Mass Spectrometry - methods ; Terpenes - analysis ; Terpenes - chemistry ; Traditional Chinese herbal formula ; Traditional Chinese medicine processing ; UHPLC/Q-TOF-MS/MS
É parte de: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2018-04, Vol.1083, p.110-123
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Baizhu Shaoyao San (BSS) is a famous traditional Chinese medicinal formula widely used for the treatment of painful diarrhea, intestinal inflammation, and diarrhea-predominant irritable bowel syndrome. According to clinical medication, three medicinal herbs (Atractylodis Macrocephalae Rhizoma, Paeoniae Radix Alba, and Citri Reticulatae Pericarpium) included in BSS must be processed using some specific methods of stir-frying. On the basis of the classical theories of traditional Chinese medicine, the therapeutic effects of BSS would be significantly enhanced after processing. Generally, the changes of curative effects mainly result from the variations of inside chemical basis caused by the processing procedure. To find out the corresponding changes of chemical compositions in BSS after processing and to elucidate the material basis of the changed curative effects, an optimized ultra-high-performance liquid chromatography-quadrupole/time-of-flight mass spectrometry in positive and negative ion modes coupled with multivariate statistical analyses were developed. As a result, a total of 186 compounds were ultimately identified in crude and processed BSS, in which 62 marker compounds with significant differences between crude and processed BSS were found by principal component analysis and t-test. Compared with crude BSS, the contents of 23 compounds were remarkably decreased and the contents of 39 compounds showed notable increase in processed BSS. The transformation mechanisms of some changed compounds were appropriately inferred from the results. Furthermore, compounds with extremely significant differences might strengthen the effects of the whole herbal formula. •An LC-MS/MS method was developed to compare the chemical profiles between crude and processed Baizhu Shaoyao San (BSS).•186 compounds were identified in BSS through the MS/MS fragmentations.•62 marker compounds between crude and processed BSS were firstly found.•The proper mechanisms for the change of constituents and effects of BSS after processing were reasonably deduced.
Editor: Netherlands: Elsevier B.V
Idioma: Inglês

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Profiling and analysis of multiple constituents in Baizhu Shaoyao San before and after processing by stir-frying using UHPLC/Q-TOF-MS/MS coupled with multivariate statistical analysis

Xu, Yangyang ; Cai, Hao ; Cao, Gang ; Duan, Yu ; Pei, Ke ; Tu, Sicong ; Zhou, Jia ; Xie, Li ; Sun, Dongdong ; Zhao, Jiayu ; Liu, Jing ; Wang, Xiaoqi ; Shen, Lin

Netherlands: Elsevier B.V

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