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Serum B‐type natriuretic peptide in the initial workup of patients with new onset ascites: A diagnostic accuracy study

Farias, Alberto Q. ; Silvestre, Odilson M. ; Garcia‐Tsao, Guadalupe ; Seguro, Luis F.B. ; Mazo, Daniel F. ; Bacal, Fernando ; Andrade, José L. ; Gonçalves, Luciana L. ; Strunz, Célia ; Ramos, Danusa S. ; Polli, Demerson ; Pugliese, Vincenzo ; Rodrigues, Ana C.T. ; Furtado, Meive S. ; Carrilho, Flair J. ; D'Albuquerque, Luiz A.C.

Hepatology (Baltimore, Md.), 2014-03, Vol.59 (3), p.1043-1051 [Periódico revisado por pares]

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Título:
Serum B‐type natriuretic peptide in the initial workup of patients with new onset ascites: A diagnostic accuracy study
Autor: Farias, Alberto Q. ; Silvestre, Odilson M. ; Garcia‐Tsao, Guadalupe ; Seguro, Luis F.B. ; Mazo, Daniel F. ; Bacal, Fernando ; Andrade, José L. ; Gonçalves, Luciana L. ; Strunz, Célia ; Ramos, Danusa S. ; Polli, Demerson ; Pugliese, Vincenzo ; Rodrigues, Ana C.T. ; Furtado, Meive S. ; Carrilho, Flair J. ; D'Albuquerque, Luiz A.C.
Assuntos: Accuracy ; Adult ; Aged ; Ascites - diagnosis ; Ascites - etiology ; Ascites - metabolism ; Cross-Sectional Studies ; Diagnosis, Differential ; Female ; Heart Failure - complications ; Heart Failure - diagnosis ; Heart Failure - metabolism ; Hepatology ; Humans ; Liver cirrhosis ; Liver Cirrhosis - complications ; Liver Cirrhosis - diagnosis ; Liver Cirrhosis - metabolism ; Male ; Middle Aged ; Natriuretic Peptide, Brain - blood ; Peritoneal Diseases - complications ; Peritoneal Diseases - diagnosis ; Peritoneal Diseases - metabolism ; Reproducibility of Results ; Sensitivity and Specificity
É parte de: Hepatology (Baltimore, Md.), 2014-03, Vol.59 (3), p.1043-1051
Notas: This work was supported by the Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP; Sao Paulo Research Foundation; grant no.: 2011/09484‐5).
Potential conflict of interest: Nothing to report.
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Descrição: Heart failure (HF) is, after cirrhosis, the second‐most common cause of ascites. Serum B‐type natriuretic peptide (BNP) plays an important role in the diagnosis of HF. Therefore, we hypothesized that BNP would be useful in the differential diagnosis of ascites. Consecutive patients with new onset ascites were prospectively enrolled in this cross‐sectional study. All patients had measurements of serum‐ascites albumin gradient (SAAG), total protein concentration in ascitic fluid, serum, and ascites BNP. We enrolled 218 consecutive patients with ascites resulting from HF (n = 44), cirrhosis (n = 162), peritoneal disease (n = 10), and constrictive pericarditis (n = 2). Compared to SAAG and/or total protein concentration in ascites, the test that best discriminated HF‐related ascites from other causes of ascites was serum BNP. A cutoff of >364 pg/mL (sensitivity 98%, specificity 99%, and diagnostic accuracy 99%) had the highest positive likelihood ratio (168.1); that is, it was the best to rule in HF‐related ascites. Conversely, a cutoff ≤182 pg/mL had the lowest negative likelihood ratio (0.0) and was the best to rule out HF‐related ascites. These findings were confirmed in a 60‐patient validation cohort. Conclusions: Serum BNP is more accurate than ascites analyses in the diagnosis of HF‐related ascites. The workup of patients with new onset ascites could be streamlined by obtaining serum BNP as an initial test and could forego the need for diagnostic paracentesis, particularly in cases where the cause of ascites is uncertain and/or could be the result of HF. (Hepatology 2014;59:1043–1051)
Editor: United States: Wiley Subscription Services, Inc
Idioma: Inglês

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Serum B‐type natriuretic peptide in the initial workup of patients with new onset ascites: A diagnostic accuracy study

United States: Wiley Subscription Services, Inc

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