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Cloning of cDNAs encoding neurotoxic peptides from the spider Phoneutria nigriventer

Kalapothakis, Evanguedes ; Penaforte, Claudia L ; Beirão, Paulo S.L ; Romano-Silva, Marco A ; Cruz, Jader S ; Prado, Marco A.M ; Guimarães, Pedro E.M ; Gomez, Marcus V ; Prado, Vania F

Toxicon (Oxford), 1998-12, Vol.36 (12), p.1843-1850 [Periódico revisado por pares]

Oxford: Elsevier Ltd

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Título:
Cloning of cDNAs encoding neurotoxic peptides from the spider Phoneutria nigriventer
Autor: Kalapothakis, Evanguedes ; Penaforte, Claudia L ; Beirão, Paulo S.L ; Romano-Silva, Marco A ; Cruz, Jader S ; Prado, Marco A.M ; Guimarães, Pedro E.M ; Gomez, Marcus V ; Prado, Vania F
Assuntos: Amino Acid Sequence ; Animal poisons toxicology. Antivenoms ; Animals ; Base Sequence ; Biological and medical sciences ; Blotting, Northern ; Cloning, Molecular - methods ; DNA, Complementary - chemistry ; Gene Library ; Medical sciences ; Molecular Sequence Data ; Neurotoxins - chemistry ; Phoneutria nigriventer ; Protein Sorting Signals - chemistry ; Recombinant Proteins ; Spider Venoms - genetics ; Spiders ; Toxicology
É parte de: Toxicon (Oxford), 1998-12, Vol.36 (12), p.1843-1850
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
Descrição: A cDNA library made from venom glands of the spider Phoneutria nigriventer was constructed and used to clone neurotoxic peptides. A cDNA of about 360 nucleotides encoding the precursor for the toxin Tx2-1 active on mammals has been isolated. The deduced amino acid sequence for the mature polypeptide confirms the polypeptide sequence previously published. In addition, two new putative toxins called Pn2-1A and Pn2-5A have been characterized and their complete amino acid sequence show 92% similarity to Tx2-1 and 94% similarity to Tx2-5 respectively. The cDNAs revealed that the precursors contain signal peptides characterized by a very hydrophobic core and a propeptide interposed between the signal sequence and the peptide toxin.
Editor: Oxford: Elsevier Ltd
Idioma: Inglês

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Cloning of cDNAs encoding neurotoxic peptides from the spider Phoneutria nigriventer

Kalapothakis, Evanguedes ; Penaforte, Claudia L ; Beirão, Paulo S.L ; Romano-Silva, Marco A ; Cruz, Jader S ; Prado, Marco A.M ; Guimarães, Pedro E.M ; Gomez, Marcus V ; Prado, Vania F

Oxford: Elsevier Ltd

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