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Effect of metformin treatment on multiple cardiovascular disease risk factors in patients with type 2 diabetes mellitus

Abbasi, Fahim ; Chu, James W ; McLaughlin, Tracey ; Lamendola, Cindy ; Leary, Elizabeth T ; Reaven, Gerald M

Metabolism, clinical and experimental, 2004-02, Vol.53 (2), p.159-164 [Periódico revisado por pares]

New York, NY: Elsevier Inc

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Título:
Effect of metformin treatment on multiple cardiovascular disease risk factors in patients with type 2 diabetes mellitus
Autor: Abbasi, Fahim ; Chu, James W ; McLaughlin, Tracey ; Lamendola, Cindy ; Leary, Elizabeth T ; Reaven, Gerald M
Assuntos: Aged ; Atherosclerosis (general aspects, experimental research) ; Biological and medical sciences ; Blood and lymphatic vessels ; Blood Glucose - metabolism ; Blood Pressure - drug effects ; Body Weight - drug effects ; Cardiology. Vascular system ; Cardiovascular Diseases - epidemiology ; Cardiovascular Diseases - prevention & control ; Cholesterol - blood ; Coronary heart disease ; Diabetes Mellitus, Type 2 - complications ; Diabetes Mellitus, Type 2 - drug therapy ; Diabetes. Impaired glucose tolerance ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Fatty Acids, Nonesterified - blood ; Female ; Glycated Hemoglobin A - metabolism ; Heart ; Humans ; Hypoglycemic Agents - therapeutic use ; Insulin - blood ; Male ; Medical sciences ; Metformin - therapeutic use ; Middle Aged ; Risk Factors ; Triglycerides - blood
É parte de: Metabolism, clinical and experimental, 2004-02, Vol.53 (2), p.159-164
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
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Descrição: In light of the conflicting results of the recent United Kingdom Prospective Study (UKPDS), where diabetic patients on metformin monotherapy had lower all-cause mortality and the addition of metformin in sulfonylurea-treated patients was associated with an increased risk of diabetes-related death, we sought to compare the effects on cardiovascular disease (CVD) risk factors of metformin monotherapy with metformin treatment when added to a sulfonylurea compound in patients with type 2 diabetes. Thirty-one volunteers with type 2 diabetes mellitus, 16 on dietary therapy and 15 on sulfonylurea monotherapy (SU), were treated with metformin for 12 weeks. Measurements were made of (1) fasting plasma glucose, hemoglobin A 1c (HbA 1c), lipid, remnant lipoprotein cholesterol (RLP-C) levels, and low-density lipoprotein (LDL) particle size; (2) daylong plasma glucose, insulin, free fatty acid (FFA), triglyceride (TG), and RLP-C concentrations; and (3) fasting levels of soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular cell adhesion molecule-1 (sVCAM-1), and soluble E-selectin (sE-selectin). Fasting plasma glucose concentrations decreased to a similar degree after treatment with metformin in both the metformin monotherapy group (12.45 ± 0.48 v 9.46 ± 0.47 mmol/L, P < .001) and the combined SU and metformin therapy group (14.09 ± 0.51 v 10.57 ± 0.85 mmol/L, P = .001). Fasting plasma lipid concentrations and LDL particle size did not significantly change in either treatment group, whereas fasting RLP-C concentrations were significantly lower in the metformin monotherapy group (0.43 ± 0.09 v 0.34 ± 0.07 mmol/L, P = .02). Daylong concentrations of plasma glucose, FFA, TG, and RLP-C were lower to a similar degree in both treatment groups, whereas daylong plasma insulin concentrations were unchanged. Fasting plasma sVCAM-1 levels were significantly lower in both the metformin monotherapy group (484 ± 19 v 446 ± 18 ng/mL, P = .02) and the combined SU and metformin therapy group (496 ± 29 v 456 ± 31 ng/mL, P = .05), whereas fasting plasma sICAM-1 and sE-selectin levels were essentially unchanged. Administration of metformin, either as monotherapy or in combination with a sulfonylurea drug, improved glycemic control and led to a decrease in several CVD risk factors in patients with type 2 diabetes.
Editor: New York, NY: Elsevier Inc
Idioma: Inglês

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Effect of metformin treatment on multiple cardiovascular disease risk factors in patients with type 2 diabetes mellitus

Abbasi, Fahim ; Chu, James W ; McLaughlin, Tracey ; Lamendola, Cindy ; Leary, Elizabeth T ; Reaven, Gerald M

New York, NY: Elsevier Inc

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