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Antidiabetic effect of Equisetum giganteum L. extract on alloxan-diabetic rabbit

Vieira, Geisla Teles ; de Oliveira, Tânia Toledo ; Carneiro, Marco Antonio Alves ; Cangussu, Silvia Dantas ; Humberto, Gabriel Almeida Paes ; Taylor, Jason Guy ; Humberto, Jorge Luiz

Journal of ethnopharmacology, 2020-10, Vol.260, p.112898, Article 112898 [Periódico revisado por pares]

Ireland: Elsevier B.V

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Título:
Antidiabetic effect of Equisetum giganteum L. extract on alloxan-diabetic rabbit
Autor: Vieira, Geisla Teles ; de Oliveira, Tânia Toledo ; Carneiro, Marco Antonio Alves ; Cangussu, Silvia Dantas ; Humberto, Gabriel Almeida Paes ; Taylor, Jason Guy ; Humberto, Jorge Luiz
Assuntos: Albumin ; Alloxan ; Analysis ; Animals ; Biomarkers - blood ; Blood Glucose - drug effects ; Blood Glucose - metabolism ; Diabetes Mellitus, Experimental - blood ; Diabetes Mellitus, Experimental - chemically induced ; Diabetes Mellitus, Experimental - drug therapy ; Diabetes Mellitus, Experimental - pathology ; Equisetum - chemistry ; Glycated Hemoglobin A - metabolism ; Glycosylated hemoglobin ; Hypoglycemic Agents - isolation & purification ; Hypoglycemic Agents - pharmacology ; Lipids - blood ; Liquid chromatography ; Liver - drug effects ; Liver - metabolism ; Liver - pathology ; Male ; Mass spectrometry ; Medicine, Botanic ; Medicine, Herbal ; Pancreas - drug effects ; Pancreas - metabolism ; Pancreas - pathology ; Plant Extracts - isolation & purification ; Plant Extracts - pharmacology ; Pyrimidines ; Rabbits
É parte de: Journal of ethnopharmacology, 2020-10, Vol.260, p.112898, Article 112898
Descrição: Equisetum giganteum has been traditionally used as an anti-diabetic herbal remedy to treat diabetes in the southern state of Rio Grande do Sul in Brazil. Considering the ethonopharmacology and historical importance of E. giganteum, its potential antidiabetic effect was evaluated in alloxan induced diabetic rabbits. Samples of Equisetum giganteum were collected in the city of Ouro Preto, Minas Gerais, Brazil. Butanolic and aqueous extracts were prepared and subsequently evaluated for anti-diabetic properties in vivo using albino male rabbits. At the end of the treatment period, the animals were euthanized, and histopathological analysis were carried out. The following biochemical parameters were studied: glucose, triacylglycerol, cholesterol, albumin, creatinine, glycosylated hemoglobin and lipase. The phytochemical profile of the extracts was studied by liquid chromatography techniques coupled to a UV/VIS detector and high-resolution mass spectrometry. Both aqueous and butanolic extracts were capable of reducing significantly the levels of glucose, cholesterol and triacylglycerol and thus demonstrating their hypolipidemic and hypoglycemiant effects. Furthermore, the extracts prevented the occurrence of hepatic complications during treatment. The phytochemical profile of the extracts was investigated, and the natural products detected were in agreement with those that had been previously described in the literature. Based on the significant reductions in biochemical parameters and the histologic evidence for the absence of complications in the liver, pancreas of the treated animals, Equisetum giganteum can be a therapeutically relevant resource in the treatment of diabetes and hyperlipidemia. [Display omitted]
Editor: Ireland: Elsevier B.V
Idioma: Inglês

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Antidiabetic effect of Equisetum giganteum L. extract on alloxan-diabetic rabbit

Vieira, Geisla Teles ; de Oliveira, Tânia Toledo ; Carneiro, Marco Antonio Alves ; Cangussu, Silvia Dantas ; Humberto, Gabriel Almeida Paes ; Taylor, Jason Guy ; Humberto, Jorge Luiz

Ireland: Elsevier B.V

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