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Regulation of Obesity and Non-alcoholic Fatty Liver Diseases by Modulation of the Gut Microbiota Through Inflammasome; its Mechanism and Potential for Clinical Use

Nam, Jae-Hwan

Journal of Bacteriology and Virology, 2012, 42(4), , pp.359-362

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Título:
Regulation of Obesity and Non-alcoholic Fatty Liver Diseases by Modulation of the Gut Microbiota Through Inflammasome; its Mechanism and Potential for Clinical Use
Autor: Nam, Jae-Hwan
Assuntos: 생물학
É parte de: Journal of Bacteriology and Virology, 2012, 42(4), , pp.359-362
Notas: KISTI1.1003/JNL.JAKO201216238705897
G704-000075.2012.42.4.006
Descrição: The revelation that gut microbes are associated with the pathogenesis of human diseases such as obesity, colon cancer, inflammatory bowel disease and liver-related diseases has resulted in the role of gut microbes becoming a novel research topic in basic and clinical science. Recently, emphasis has been placed on the role of gut microbes in non-alcoholic fatty liver disease (NAFLD) and its progressive form, non-alcoholic steatohepatitis (NASH). Researchers have suggested that inflammasome deficiency-changed dysbiosis is associated with exacerbating NAFLD/NASH progression. This particular study also showed a direct 'gut-liver axis' regulated by modulation of gut microbiota. This paper (Nature 2012;482: 179-185) was summarized herein and the potential clinical applications were discussed.
Editor: 대한미생물학회
Idioma: Coreano

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