Exploration of beta-turn scaffolding motifs as components of sialyl Le(X) mimetics and their relevance to P-selectin

• Autor: Hanessian, S ; Huynh, H K ; Reddy, G V ; McNaughton-Smith, G ; Ernst, B ; Kolb, H C ; Magnani, J ; Sweeley, C
• Assuntos: beta-Lactams - chemical synthesis ; beta-Lactams - chemistry ; beta-Lactams - metabolism ; Binding, Competitive ; Carbohydrate Conformation ; Carbohydrate Sequence ; E-Selectin - metabolism ; Indolizines - chemical synthesis ; Indolizines - chemistry ; Indolizines - metabolism ; Molecular Sequence Data ; Oligosaccharides - chemical synthesis ; Oligosaccharides - chemistry ; Oligosaccharides - metabolism ; P-Selectin - metabolism ; Structure-Activity Relationship ; Substrate Specificity
• É parte de: Bioorganic & medicinal chemistry letters, 1998-10, Vol.8 (19), p.2803-2808
• Notas: ObjectType-Article-1
  SourceType-Scholarly Journals-1
  ObjectType-Feature-2
  content type line 23
  
• Descrição: Monocyclic and bicyclic lactam units representing beta-turn surrogates were incorporated into a sialyl Le(X) structure by replacement of the natural sugar components. Low micromolar activity was found in a new P-selectin binding assay.
  
• Editor: England
  
• Idioma: Inglês