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The inflammatory response in the regression of lumbar disc herniation

Cunha, Carla ; Silva, Ana J ; Pereira, Paulo ; Vaz, Rui ; Gonçalves, Raquel M ; Barbosa, Mário A

Arthritis research & therapy, 2018-11, Vol.20 (1), p.251-251, Article 251 [Periódico revisado por pares]

England: BioMed Central Ltd

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Título:
The inflammatory response in the regression of lumbar disc herniation
Autor: Cunha, Carla ; Silva, Ana J ; Pereira, Paulo ; Vaz, Rui ; Gonçalves, Raquel M ; Barbosa, Mário A
Assuntos: Angiogenesis ; Arthritis ; Back pain ; Care and treatment ; Collagen ; Development and progression ; Hernia ; Humans ; Immune response ; Immunomodulation ; Inflammation ; Inflammation - diagnostic imaging ; Inflammation - epidemiology ; Inflammation - immunology ; Intervertebral disc ; Intervertebral Disc Degeneration - diagnostic imaging ; Intervertebral Disc Degeneration - epidemiology ; Intervertebral Disc Degeneration - immunology ; Intervertebral Disc Displacement - diagnostic imaging ; Intervertebral Disc Displacement - epidemiology ; Intervertebral Disc Displacement - immunology ; Intervertebral disk ; Intervertebral disk displacement ; Low back pain ; Low Back Pain - diagnostic imaging ; Low Back Pain - epidemiology ; Low Back Pain - immunology ; Lumbar Vertebrae - diagnostic imaging ; Lumbar Vertebrae - immunology ; Macrophages ; Medical imaging ; NMR ; Nuclear magnetic resonance ; Observations ; Patients ; Remission, Spontaneous ; Review ; Spine ; Stem cells ; Vascular endothelial growth factor
É parte de: Arthritis research & therapy, 2018-11, Vol.20 (1), p.251-251, Article 251
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Descrição: Lumbar disc herniation (LDH) is highly associated with inflammation in the context of low back pain. Currently, inflammation is associated with adverse symptoms related to the stimulation of nerve fibers that may lead to pain. However, inflammation has also been indicated as the main factor responsible for LDH regression. This apparent controversy places inflammation as a good prognostic indicator of spontaneous regression of LDH. This review addresses the molecular and cellular mechanisms involved in LDH regression, including matrix remodeling and neovascularization, in the scope of the clinical decision on conservative versus surgical intervention. Based on the evidence, a special focus on the inflammatory response in the LDH context is given, particularly in the monocyte/macrophage role. The phenomenon of spontaneous regression of LDH, extensively reported in the literature, is therefore analyzed here under the perspective of the modulatory role of inflammation.
Editor: England: BioMed Central Ltd
Idioma: Inglês

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The inflammatory response in the regression of lumbar disc herniation

Cunha, Carla ; Silva, Ana J ; Pereira, Paulo ; Vaz, Rui ; Gonçalves, Raquel M ; Barbosa, Mário A

England: BioMed Central Ltd

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