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The maintenance of hippocampal long-term potentiation is paralleled by a dopamine-dependent increase in glycoprotein fucosylation

Angenstein, F. ; Matthies, H. ; Staeck, S. ; Reymann, K.G. ; Staak, S.

Neurochemistry international, 1992-10, Vol.21 (3), p.403-408 [Periódico revisado por pares]

OXFORD: Elsevier Ltd

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Título:
The maintenance of hippocampal long-term potentiation is paralleled by a dopamine-dependent increase in glycoprotein fucosylation
Autor: Angenstein, F. ; Matthies, H. ; Staeck, S. ; Reymann, K.G. ; Staak, S.
Assuntos: Animals ; Benzazepines - pharmacology ; Biochemistry & Molecular Biology ; Biochemistry and metabolism ; Biological and medical sciences ; Carbon Radioisotopes ; Central nervous system ; Dopamine - physiology ; Electric Stimulation ; Fucose - metabolism ; Fundamental and applied biological sciences. Psychology ; Glycoproteins - biosynthesis ; Hippocampus - drug effects ; Hippocampus - metabolism ; Hippocampus - physiology ; In Vitro Techniques ; Kinetics ; Leucine - metabolism ; Life Sciences & Biomedicine ; Male ; Membrane Potentials - drug effects ; Nerve Tissue Proteins - biosynthesis ; Neurosciences ; Neurosciences & Neurology ; Phosphotransferases (Alcohol Group Acceptor) ; Phosphotransferases - metabolism ; Pyramidal Tracts - drug effects ; Pyramidal Tracts - metabolism ; Pyramidal Tracts - physiology ; Rats ; Rats, Wistar ; Receptors, Dopamine D1 - antagonists & inhibitors ; Science & Technology ; Time Factors ; Tritium ; Vertebrates: nervous system and sense organs
É parte de: Neurochemistry international, 1992-10, Vol.21 (3), p.403-408
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Descrição: Induction of long-term potentiation (LTP) in hippocampal slices of rats caused an increase in both protein synthesis and glycoprotein fucosylation by 38 and 34%, respectively. The enhanced incorporation of [3H]fucose into glycoproteins observed 1 h after tetanization was abolished in the presence of the dopamine D1 receptor antagonist SCH23390 during stimulation whereas the LTP-induced increase of protein synthesis was not influenced by this drug. The enhanced insertion of [3H]fucose into hippocampal glycoproteins 1 h after tetanization was paralleled by an increase in the activity of the fucose metabolizing enzyme, fucokinase. In contrast no changes in protein and glycoprotein synthesis were detectable 5 h after tetanization of the slices. The results provide evidence that in addition to an enhanced protein synthesis a dopamine (D1) mediated increase in glycoprotein fucosylation is necessary for the maintenance of the late stage of LTP.
Editor: OXFORD: Elsevier Ltd
Idioma: Inglês

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The maintenance of hippocampal long-term potentiation is paralleled by a dopamine-dependent increase in glycoprotein fucosylation

Angenstein, F. ; Matthies, H. ; Staeck, S. ; Reymann, K.G. ; Staak, S.

OXFORD: Elsevier Ltd

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