skip to main content
Idioma:

Pattern recognition receptors in annelids

Prochazkova, P. ; Roubalova, R. ; Dvorak, J. ; Navarro Pacheco, N.I. ; Bilej, M.

Developmental and comparative immunology, 2020-01, Vol.102, p.103493-103493, Article 103493 [Periódico revisado por pares]

United States: Elsevier Ltd

Texto completo disponível

Citações Citado por
  • Título:
    Pattern recognition receptors in annelids
  • Autor: Prochazkova, P. ; Roubalova, R. ; Dvorak, J. ; Navarro Pacheco, N.I. ; Bilej, M.
  • Assuntos: Adaptive control ; Annelida ; Antibodies ; CCF ; Discrimination ; Earthworm ; Immune system ; Immunity ; Inflammation ; Innate immunity ; Intracellular signalling ; Invertebrates ; LBP ; Lymphocytes ; Medical immunity ; Microorganisms ; PAMP ; Pattern recognition ; Pattern recognition receptors ; Phenoloxidase cascade ; PRR ; Receptors ; TLR
  • É parte de: Developmental and comparative immunology, 2020-01, Vol.102, p.103493-103493, Article 103493
  • Notas: ObjectType-Article-2
    SourceType-Scholarly Journals-1
    ObjectType-Feature-3
    content type line 23
    ObjectType-Review-1
  • Descrição: The existence of pattern recognition receptors (PRRs) on immune cells was discussed in 1989 by Charles Janeway, Jr., who proposed a general concept of the ability of PRRs to recognize and bind conserved molecular structures of microorganisms known as pathogen-associated molecular patterns (PAMPs). Upon PAMP engagement, PRRs trigger intracellular signaling cascades resulting in the expression of various proinflammatory molecules. These recognition molecules represent an important and efficient innate immunity tool of all organisms. As invertebrates lack the instruments of the adaptive immune system, based on “true” lymphocytes and functional antibodies, the importance of PRRs are even more fundamental. In the present review, the structure, specificity, and expression profiles of PRRs characterized in annelids are discussed, and their role in innate defense is suggested. [Display omitted] •PRRs represents essential tools of innate immunity in annelids.•Two LPS-binding proteins, CCF and EaLBP/BPI, differ in their tissue distribution.•Single cysteine cluster EaTLR participates in the innate immunity mechanisms.•Multiple cysteine cluster mccEaTLR is supposed to play a role in early development of earthworms.•Both TLRs differ in the sequence variability, in the presence of introns and their tissue distribution.
  • Editor: United States: Elsevier Ltd
  • Idioma: Inglês
Links
Voltar para lista de resultados

  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

Buscando em bases de dados remotas. Favor aguardar.