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SYNTHESIS, CHARACTERIZATION AND CYTOTOXIC ACTIVITY EVALUATION OF CYCLOPALLADATED COMPOUNDS CONTAINING ORTHOMETALLATED BENZALDEHYDEOXIME AND ETHYLENETHIOUREA AS LIGANDS

Nathália A. Thomazella ; Lemos, Sahra C. ; Souza, Ronan F. F. De ; Souza, Rodrigo A. De ; Mauro, Antonio E. ; Iracilda Z. Carlos ; Netto, Adelino V. G.

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Título:
SYNTHESIS, CHARACTERIZATION AND CYTOTOXIC ACTIVITY EVALUATION OF CYCLOPALLADATED COMPOUNDS CONTAINING ORTHOMETALLATED BENZALDEHYDEOXIME AND ETHYLENETHIOUREA AS LIGANDS
Autor: Nathália A. Thomazella ; Lemos, Sahra C. ; Souza, Ronan F. F. De ; Souza, Rodrigo A. De ; Mauro, Antonio E. ; Iracilda Z. Carlos ; Netto, Adelino V. G.
Assuntos: FOS: Chemical sciences ; Physical Chemistry not elsewhere classified
Notas: 10.21577/0100-4042.20170293
RelationTypeNote: IsSupplementTo -- 10.21577/0100-4042.20170293
Descrição: The halide-bridge cleavage reaction of the [Pd(C2 ,N-bzox)(µ-Cl)]2 compound (bzox = benzaldehydeoxime) with ethylenethiourea (L) in the 1:2 molar ratio at room temperature yielded the cyclopalladated compound [Pd(C2 ,N-bzox)(Cl)(L)] (1) whose replacement of the halide group by the addition of suitable salts afforded compounds of general formulae [Pd(C2 ,N-bzox)(X)(L)] {X = Br- (2), I- (3)}. All compounds were characterized by melting point, elemental analyses, infrared and 1H- and 13C{1H}-NMR spectroscopies revealing the complexes formation with the oxime coordinated to Pd(II) as C,N-chelating and the ethylenethiourea as a monodentate ligand via the sulfur atom. The cytotoxicity of cyclopalladated compounds has been evaluated in vitro against murine mammary tumor cell (LM3) showing cytotoxic activity similar to cisplatin.
Editor: SciELO journals
Data de criação/publicação: 2018
Idioma: Inglês

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