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Cytotoxic activity of nemorosone in human MCF-7 breast cancer cells

Popolo, Ada ; Piccinelli, Anna Lisa ; Morello, Silvana ; Sorrentino, Rosalinda ; Osmany, Cuesta Rubio ; Rastrelli, Luca ; Aldo, Pinto

Canadian journal of physiology and pharmacology, 2011-01, Vol.89 (1), p.50-57 [Periódico revisado por pares]

Plattsburgh, NY: National Research Council of Canada

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Título:
Cytotoxic activity of nemorosone in human MCF-7 breast cancer cells
Autor: Popolo, Ada ; Piccinelli, Anna Lisa ; Morello, Silvana ; Sorrentino, Rosalinda ; Osmany, Cuesta Rubio ; Rastrelli, Luca ; Aldo, Pinto
Assuntos: Antimitotic agents ; Antineoplastic agents ; Antineoplastic Agents, Phytogenic - isolation & purification ; Antineoplastic Agents, Phytogenic - therapeutic use ; Antineoplastic Agents, Phytogenic - toxicity ; Benzophenones - isolation & purification ; Benzophenones - therapeutic use ; Benzophenones - toxicity ; Biological and medical sciences ; Breast cancer ; Breast Neoplasms - drug therapy ; Breast Neoplasms - pathology ; Calcium Signaling - drug effects ; Calcium Signaling - physiology ; Cancer ; Cancer cells ; cancer du sein ; Care and treatment ; Cell growth ; Cell Line, Tumor ; Cell Survival - drug effects ; Cell Survival - physiology ; Clusia ; croissance cellulaire ; Cytotoxins - isolation & purification ; Cytotoxins - therapeutic use ; Cytotoxins - toxicity ; Estrogen ; estrogen receptor ; Estrogens ; Female ; Fundamental and applied biological sciences. Psychology ; Humans ; nemorosone ; némorosone ; Plant Extracts - isolation & purification ; Plant Extracts - therapeutic use ; Plant Extracts - toxicity ; Properties ; Receptors ; récepteurs des œstrogènes ; Studies ; Vertebrates: anatomy and physiology, studies on body, several organs or systems
É parte de: Canadian journal of physiology and pharmacology, 2011-01, Vol.89 (1), p.50-57
Descrição: Estrogen receptor (ER) antagonists have been widely used for breast cancer treatment;; however, patients have increasingly shown resistance and sensitivity to the high toxicity of these drugs, and identification of novel targeted therapies is therefore required. To determine whether nemorosone, a polycyclic polyisoprenylated benzophenone isolated from floral resins of Clusia rosea Jacq. and Cuban propolis samples, exerts anticancer effects on human breast cancer cells, estrogen receptor positive (ER α+) MCF-7 and estrogen receptor negative (ER α-) MDA-MB-231 and LNCaP cells were used. Cells were treated with nemorosone alone or in association with 17 β-estradiol (E2) or an ER antagonist, ICI 182,780, a selective ER downregulator that completely abrogates estrogen-sensitive gene transcription. Nemorosone inhibited the cell viability of ER α+ but not of ER α- cells. In MCF-7, nemorosone induced inhibition of cell growth by blocking the cell cycle in the G 0 /G 1 phase. Moreover, the expression of pERK1/2 and pAkt, considered to be hallmarks of the nongenomic estrogen signalling pathway, were reduced in MCF-7 cells treated with nemorosone. All these effects were enhanced by ICI 182,780. However, nemorosone was not able to interfere with E2-induced Ca 2+ release. These findings suggest that nemorosone may have therapeutic application in the treatment of breast cancer because of its activity on ER α.
Editor: Plattsburgh, NY: National Research Council of Canada
Idioma: Inglês

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Cytotoxic activity of nemorosone in human MCF-7 breast cancer cells

Popolo, Ada ; Piccinelli, Anna Lisa ; Morello, Silvana ; Sorrentino, Rosalinda ; Osmany, Cuesta Rubio ; Rastrelli, Luca ; Aldo, Pinto

Plattsburgh, NY: National Research Council of Canada

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