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Serum concentrations of macrophage inhibitory cytokine 1 (MIC 1) as a predictor of miscarriage

Tong, Stephen ; Marjono, Budi ; Brown, David A ; Mulvey, Sheila ; Breit, Samuel N ; Manuelpillai, Ursula ; Wallace, Euan M

The Lancet (British edition), 2004-01, Vol.363 (9403), p.129-130 [Periódico revisado por pares]

England: Elsevier Ltd

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Título:
Serum concentrations of macrophage inhibitory cytokine 1 (MIC 1) as a predictor of miscarriage
Autor: Tong, Stephen ; Marjono, Budi ; Brown, David A ; Mulvey, Sheila ; Breit, Samuel N ; Manuelpillai, Ursula ; Wallace, Euan M
Assuntos: Abortion, Spontaneous - blood ; Abortion, Spontaneous - diagnosis ; Abortion, Spontaneous - prevention & control ; Biomarkers - blood ; Cytokines ; Cytokines - blood ; Cytokines - physiology ; Diagnosis ; Female ; Fetal Viability - physiology ; Fetuses ; Gestation ; Gestational Age ; Government agencies ; Growth Differentiation Factor 15 ; Hormones ; Humans ; Immune system ; Immunomodulation ; Macrophages ; Minimum inhibitory concentration ; Miscarriage ; Predictive Value of Tests ; Pregnancy ; Pregnancy Trimester, First ; R&D ; Research & development ; Ultrasonic imaging ; Viability
É parte de: The Lancet (British edition), 2004-01, Vol.363 (9403), p.129-130
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Macrophage inhibitory cytokine 1 (MIC 1) is thought to have immunomodulatory actions favouring fetal viability. We measured serum concentrations of MIC 1 in asymptomatic women at 6–13 weeks' gestation who subsequently miscarried or who had already miscarried. MIC 1 concentrations in the miscarriage cohort (n=100), were a third of those who had ongoing pregnancies (n=197). Multiples of the median for miscarriage was 0·32 (95% CI 0·23–0·32) versus1·00 (0·93–1·06) for ongoing pregnancies; p<0·0001. Concentrations were just as low 3 weeks before diagnosis as on the day of diagnosis. That MIC 1 serum concentrations seem to be low weeks before miscarriage suggests possible predictive and causative roles, as well as therapeutic potential.
Editor: England: Elsevier Ltd
Idioma: Inglês

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Serum concentrations of macrophage inhibitory cytokine 1 (MIC 1) as a predictor of miscarriage

Tong, Stephen ; Marjono, Budi ; Brown, David A ; Mulvey, Sheila ; Breit, Samuel N ; Manuelpillai, Ursula ; Wallace, Euan M

England: Elsevier Ltd

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