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Opioid Systems and the Regulation of Mood: Possible Significance in Depression?

Herz, A. ; Emrich, H. M. Angst, J.

The Origins of Depression: Current Concepts and Approaches, p.221-234

Berlin, Heidelberg: Springer Berlin Heidelberg

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  • Título:
    Opioid Systems and the Regulation of Mood: Possible Significance in Depression?
  • Autor: Herz, A. ; Emrich, H. M.
  • Angst, J.
  • Assuntos: Affective Disorder ; Depressed Patient ; Opiate Receptor ; Opioid Peptide ; Opioid System
  • É parte de: The Origins of Depression: Current Concepts and Approaches, p.221-234
  • Descrição: The aim of the present paper is to evaluate a possible functional role of opioids in the regulation of mood in view of a hypothetical deficiency of endorphinergic activity in endogenous depression. It has clearly been demonstrated that endorphins play an important role in the rewarding process of electrical self-stimulation. Furthermore, the euphorogenic, anxiolytic and tranquilizing properties of opioids, the antidepressant effects of β-endorphin and buprenorphine, and the inducibility of a depression-like syndrome by chronic naltrexone application are in favor of a possible functional role of opioid systems in the pathogenesis of affective disorders. Additionally, the finding that electroconvulsion activates endorphins in the central nervous system and that in depressed patients a blunted prolactin response upon morphine administration can be observed, supports such a concept. Nevertheless, it cannot be ruled out that the beneficial effects of opioids in endogenous depression represent only symptomatic influences upon depressive syndromes and do not compensate for a hypothetical deficiency in endorphinergic activity.
  • Títulos relacionados: Dahlem Workshop Reports Life Sciences Research Report
  • Editor: Berlin, Heidelberg: Springer Berlin Heidelberg
  • Idioma: Inglês
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