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Pregnancy and COVID-19: management and challenges

Wenling, Yao ; Junchao, Qiu ; Xiao, Zhirong ; Ouyang, Shi

Revista do Instituto de Medicina Tropical de São Paulo, 2020-01, Vol.62, p.e62-9 [Periódico revisado por pares]

Brazil: Instituto de Medicina Tropical de Sao Paulo

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  • Título:
    Pregnancy and COVID-19: management and challenges
  • Autor: Wenling, Yao ; Junchao, Qiu ; Xiao, Zhirong ; Ouyang, Shi
  • Assuntos: Betacoronavirus ; Brazil ; Coronavirus Infections - diagnosis ; Coronavirus Infections - therapy ; COVID-19 ; Female ; Humans ; Infant, Newborn ; MERS ; Neonates ; Pandemics ; Pneumonia, Viral - diagnosis ; Pneumonia, Viral - therapy ; Pregnancy ; Pregnancy Complications, Infectious - virology ; Review ; SARS ; SARS-CoV-2 ; TROPICAL MEDICINE ; Vertical transmission
  • É parte de: Revista do Instituto de Medicina Tropical de São Paulo, 2020-01, Vol.62, p.e62-9
  • Notas: ObjectType-Article-2
    SourceType-Scholarly Journals-1
    ObjectType-Feature-3
    content type line 23
    ObjectType-Review-1
    Yao W, Qiu J and Xiao Z had the idea for the article and performed the literature search and data analysis. The first draft of the manuscript was written by Yao W and all authors critically revised the previous versions of the manuscript. All authors read and approved the final manuscript.
    CONFLICT OF INTERESTS
    We declare no conflict of interests.
    AUTHORS’ CONTRIBUTIONS
    These authors should be considered joint first authors
  • Descrição: The consequences of COVID-19 infecting pregnant women and the potential risks of vertical transmission have become a major issue. Since little is currently known about COVID-19 in pregnancy, the understanding of COVID-19 in this particular group will be updated in time, and a comprehensive review will be useful to evaluate the impact of COVID-19 in pregnancy. Based on recently published literature and official documents, this review provides an introduction to the pathogenesis, pathology, and clinical features of COVID-19 and has focused on the current researches on clinical features, pregnancy outcomes and placental histopathological analysis from pregnant women infected with SARS-CoV-2 in comparison with SARS-CoV and MERS-CoV. These viruses trigger a cytokine storm in the body, produce a series of immune responses, and cause changes in peripheral leukocytes and immune system cells leading to pregnancy complications that may be associated with viral infections. The expression of ACE2 receptors in the vascular endothelium may explain the histological changes of placentas from pregnant women infected by SARS-CoV-2. Pregnant women with COVID-19 pneumonia show similar clinical characteristics compared with non-pregnant counterparts. Although there is no unequivocal evidence to support the fetal infection by intrauterine vertical transmission of SARS, MERS and SARS-CoV-2 so far, more and more articles began to report maternal deaths due to COVID-19. In particular, from February 26, 2020 (date of the first COVID-19 case reported in Brazil) until June 18, 2020, Brazil reported 124 maternal deaths. Therefore, pregnant women and neonates require special attention regarding the prevention, diagnosis and management of COVID-19.
  • Editor: Brazil: Instituto de Medicina Tropical de Sao Paulo
  • Idioma: Inglês;Português
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