Idioma:

Differences in the ability of yohimbine to antagonize the hypotensive effect of clonidine in normotensive and spontaneously hypertensive anesthetized rats

TIBIRICA, E ; FELDMAN, J ; BOUSQUET, P

The Journal of pharmacology and experimental therapeutics, 1988-03, Vol.244 (3), p.1062-1066 [Periódico revisado por pares]

Bethesda, MD: American Society for Pharmacology and Experimental Therapeutics

Texto completo disponível

Citações Citado por

Enviar para

Título:
Differences in the ability of yohimbine to antagonize the hypotensive effect of clonidine in normotensive and spontaneously hypertensive anesthetized rats
Autor: TIBIRICA, E ; FELDMAN, J ; BOUSQUET, P
Assuntos: Animals ; Antihypertensive agents ; Biological and medical sciences ; Blood Pressure - drug effects ; Cardiovascular system ; Clonidine - pharmacology ; Dose-Response Relationship, Drug ; Hypertension - physiopathology ; Medical sciences ; Pharmacology. Drug treatments ; Rats ; Rats, Inbred SHR ; Rats, Inbred WKY ; Receptors, Adrenergic, alpha - physiology ; Yohimbine - pharmacology
É parte de: The Journal of pharmacology and experimental therapeutics, 1988-03, Vol.244 (3), p.1062-1066
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Low doses of yohimbine (1, 5 and 10 micrograms/kg), injected i.c.v. to spontaneously hypertensive rats as pretreatment, prevented the hypotensive effect of clonidine (standard dose of 5 micrograms/kg). At the opposite, the same doses of yohimbine did not influence the hypotensive effect of clonidine in control groups of normotensive animals (Wistar-Kyoto rats) treated under the same conditions. Interestingly, we observed that the central hypotensive effect of clonidine was greater in the hypertensive animals than in normotensive rats. Thus, we concluded that the central hypotensive effect of clonidine is affected by very low doses of yohimbine in spontaneously hypertensive rats and not in normotensive control animals. The yohimbine insensitive effect might be due to the action of clonidine on one type of medullary receptors specific to the imidazoline structure. On the physiopathological side, it seems therefore that, in hypertensive animals, there is a yohimbine sensitive mechanism, perhaps an alpha-2 adrenoceptor stimulating effect, which is nonexistent in normotensive animals.
Editor: Bethesda, MD: American Society for Pharmacology and Experimental Therapeutics
Idioma: Inglês

Links

Voltar para lista de resultados

Anterior Resultado 6 Avançar Ir para próxima página

Realização: Logos de Redes Sociais:

Differences in the ability of yohimbine to antagonize the hypotensive effect of clonidine in normotensive and spontaneously hypertensive anesthetized rats

TIBIRICA, E ; FELDMAN, J ; BOUSQUET, P

Bethesda, MD: American Society for Pharmacology and Experimental Therapeutics

Buscando em bases de dados remotas. Favor aguardar.