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microRNAs deregulation in head and neck squamous cell carcinoma

Carron, Juliana ; Torricelli, Caroline ; Silva, Janet K. ; Queiroz, Gabriela S. R. ; Ortega, Manoela M. ; Lima, Carmen S. P. ; Lourenço, Gustavo J.

Head & neck, 2021-02, Vol.43 (2), p.645-667 [Periódico revisado por pares]

Hoboken, USA: John Wiley & Sons, Inc

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  • Título:
    microRNAs deregulation in head and neck squamous cell carcinoma
  • Autor: Carron, Juliana ; Torricelli, Caroline ; Silva, Janet K. ; Queiroz, Gabriela S. R. ; Ortega, Manoela M. ; Lima, Carmen S. P. ; Lourenço, Gustavo J.
  • Assuntos: Apoptosis ; Cell cycle ; Cell differentiation ; Epigenetics ; Gene expression ; Head & neck cancer ; head and neck cancer ; MicroRNAs ; miRNA ; SNVs ; Squamous cell carcinoma ; therapy ; Tobacco ; Tumor cells
  • É parte de: Head & neck, 2021-02, Vol.43 (2), p.645-667
  • Notas: ObjectType-Article-2
    SourceType-Scholarly Journals-1
    ObjectType-Feature-3
    content type line 23
    ObjectType-Review-1
  • Descrição: Head and neck (HN) squamous cell carcinoma (SCC) is the eighth most common human cancer worldwide. Besides tobacco and alcohol consumption, genetic and epigenetic alterations play an important role in HNSCC occurrence and progression. microRNAs (miRNAs) are small noncoding RNAs that regulate cell cycle, proliferation, development, differentiation, and apoptosis by interfering in gene expression. Expression profiling of miRNAs showed that some miRNAs are upregulated or downregulated in tumor cells when compared with the normal cells. The present review focuses on the role of miRNAs deregulations in HNSCC, enrolled in risk, development, outcome, and therapy sensitivity. Moreover, the influence of single nucleotide variants in miRNAs target sites, miRNAs seed sites, and miRNAs‐processing genes in HNSCC was also revised. Due to its potential for cancer diagnosis, progression, and as a therapeutic target, miRNAs may bring new perspectives in HNSCC understanding and therapy, especially for those patients with no or insufficient treatment options.
  • Editor: Hoboken, USA: John Wiley & Sons, Inc
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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