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Antibiotics for 3rd and 4th Degree Vaginal Lacerations, Uterine Tamponade, and Manual Placental Extraction

Stern-Ascher, Conrad N. ; Huang, Yongmei ; Duffy, Cassandra R. ; Andrikopoulou, Maria ; Wright, Jason D. ; Goffman, Dena ; D'Alton, Mary E. ; Friedman, Alexander M.

American journal of perinatology, 2020-01, Vol.37 (1), p.092-103 [Periódico revisado por pares]

333 Seventh Avenue, New York, NY 10001, USA: Thieme Medical Publishers

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  • Título:
    Antibiotics for 3rd and 4th Degree Vaginal Lacerations, Uterine Tamponade, and Manual Placental Extraction
  • Autor: Stern-Ascher, Conrad N. ; Huang, Yongmei ; Duffy, Cassandra R. ; Andrikopoulou, Maria ; Wright, Jason D. ; Goffman, Dena ; D'Alton, Mary E. ; Friedman, Alexander M.
  • Assuntos: SMFM 2019
  • É parte de: American journal of perinatology, 2020-01, Vol.37 (1), p.092-103
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
  • Descrição: Abstract Objective  Trends in use of antibiotics during delivery hospitalizations complicated by (1) 3rd/4th degree vaginal lacerations, (2) manual placenta extraction, and (3) uterine tamponade are not well characterized. The objective of this study was to analyze trends in antibiotic use during vaginal delivery hospitalizations complicated by these three clinical scenarios. Study Design  An administrative inpatient database was used to perform a serial cross-sectional analysis of antibiotic administration during delivery hospitalizations in the United States from January 2006 to March 2015. The primary outcome was receipt of antibiotics during vaginal delivery hospitalizations complicated by (1) 3rd and 4th degree vaginal lacerations, (2) manual placenta extraction, and (3) uterine tamponade. Patients with other indications for antibiotics were excluded. The Cochran–Armitage test was used to assess trends. Adjusted log linear regression analyses including demographic, hospital, and obstetric factors were performed to analyze factors associated with antibiotic receipt for each of these three clinical scenarios in both primary and sensitivity analyses. Results  From 2006 to 2015 the rate of antibiotic administration during delivery hospitalizations decreased from 43.1% in 2006 to 25.5% for 3rd and 4th degree lacerations and from 59.6% to 49.2% for manual extraction ( p  < 0.01). Administration of antibiotics in the setting of uterine tamponade decreased from 48.6% in 2006 to 27.6% in 2009 before rising to 62.5% in the first quarter of 2015. In adjusted analyses, comparing the first quarter of 2015 to 2006 adjusted risk ratios for antibiotic administration were 0.61 (95% confidence interval [CI] 0.56–0.66) for 3rd and 4th degree vaginal lacerations, 0.76 (95% CI 0.53–1.09) for manual placental extraction, and 0.83 (95% CI 0.76–0.92) for uterine tamponade. Conclusion  Antibiotics are not used consistently during vaginal deliveries complicated by 3rd/4th degree lacerations, manual placenta extraction, and uterine tamponade. These findings support that a significant opportunity exists for comparative effectiveness research to assist in characterizing best practices.
  • Editor: 333 Seventh Avenue, New York, NY 10001, USA: Thieme Medical Publishers
  • Idioma: Inglês

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