Idioma:

p.Q192R SNP of PON1 seems not to be Associated with Carotid Atherosclerosis Risk Factors in an Asymptomatic and Normolipidemic Brazilian Population Sample

Scherrer, Daniel Zanetti ; Zago, Vanessa Helena de Souza ; Vieira, Isabela Calanca ; Parra, Eliane Soler ; Panzoldo, Natália Baratella ; Alexandre, Fernanda ; Secolin, Rodrigo ; Baracat, Jamal ; Quintão, Eder Carlos Rocha ; Faria, Eliana Cotta de

Arquivos brasileiros de cardiologia, 2015-07, Vol.105 (1), p.45-52 [Periódico revisado por pares]

Brazil: Sociedade Brasileira de Cardiologia

Texto completo disponível

Citações Citado por

Enviar para

Título:
p.Q192R SNP of PON1 seems not to be Associated with Carotid Atherosclerosis Risk Factors in an Asymptomatic and Normolipidemic Brazilian Population Sample
Autor: Scherrer, Daniel Zanetti ; Zago, Vanessa Helena de Souza ; Vieira, Isabela Calanca ; Parra, Eliane Soler ; Panzoldo, Natália Baratella ; Alexandre, Fernanda ; Secolin, Rodrigo ; Baracat, Jamal ; Quintão, Eder Carlos Rocha ; Faria, Eliana Cotta de
Assuntos: Adult ; Aged ; Aryldialkylphosphatase - blood ; Aryldialkylphosphatase - genetics ; Brazil ; CARDIAC & CARDIOVASCULAR SYSTEMS ; Carotid Artery Diseases - diagnostic imaging ; Carotid Artery Diseases - ethnology ; Carotid Artery Diseases - genetics ; Carotid Intima-Media Thickness ; Doenças das Artérias Carótidas / fisiopatologia ; Female ; Genetic Association Studies ; Humans ; Lipoproteins - blood ; Lipoproteins - genetics ; Lipoproteínas HDL ; Male ; Middle Aged ; Original ; Paraoxonase-1 / genética ; Polimorfismo Genético ; Polymorphism, Single Nucleotide ; Real-Time Polymerase Chain Reaction ; Reference Values ; Regression Analysis ; Risk Factors ; Young Adult
É parte de: Arquivos brasileiros de cardiologia, 2015-07, Vol.105 (1), p.45-52
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Evidences suggest that paraoxonase 1 (PON1) confers important antioxidant and anti-inflammatory properties when associated with high-density lipoprotein (HDL). To investigate the relationships between p.Q192R SNP of PON1, biochemical parameters and carotid atherosclerosis in an asymptomatic, normolipidemic Brazilian population sample. We studied 584 volunteers (females n = 326, males n = 258; 19-75 years of age). Total genomic DNA was extracted and SNP was detected in the TaqMan® SNP OpenArray® genotyping platform (Applied Biosystems, Foster City, CA). Plasma lipoproteins and apolipoproteins were determined and PON1 activity was measured using paraoxon as a substrate. High-resolution β-mode ultrasonography was used to measure cIMT and the presence of carotid atherosclerotic plaques in a subgroup of individuals (n = 317). The presence of p.192Q was associated with a significant increase in PON1 activity (RR = 12.30 (11.38); RQ = 46.96 (22.35); QQ = 85.35 (24.83) μmol/min; p < 0.0001), HDL-C (RR= 45 (37); RQ = 62 (39); QQ = 69 (29) mg/dL; p < 0.001) and apo A-I (RR = 140.76 ± 36.39; RQ = 147.62 ± 36.92; QQ = 147.49 ± 36.65 mg/dL; p = 0.019). Stepwise regression analysis revealed that heterozygous and p.192Q carriers influenced by 58% PON1 activity towards paraoxon. The univariate linear regression analysis demonstrated that p.Q192R SNP was not associated with mean cIMT; as a result, in the multiple regression analysis, no variables were selected with 5% significance. In logistic regression analysis, the studied parameters were not associated with the presence of carotid plaques. In low-risk individuals, the presence of the p.192Q variant of PON1 is associated with a beneficial plasma lipid profile but not with carotid atherosclerosis.
Editor: Brazil: Sociedade Brasileira de Cardiologia
Idioma: Inglês;Português

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Anterior Resultado 5 Avançar Ir para próxima página

Realização: Logos de Redes Sociais:

p.Q192R SNP of PON1 seems not to be Associated with Carotid Atherosclerosis Risk Factors in an Asymptomatic and Normolipidemic Brazilian Population Sample

Scherrer, Daniel Zanetti ; Zago, Vanessa Helena de Souza ; Vieira, Isabela Calanca ; Parra, Eliane Soler ; Panzoldo, Natália Baratella ; Alexandre, Fernanda ; Secolin, Rodrigo ; Baracat, Jamal ; Quintão, Eder Carlos Rocha ; Faria, Eliana Cotta de

Brazil: Sociedade Brasileira de Cardiologia

Buscando em bases de dados remotas. Favor aguardar.