Mitofusin-2 triggers mitochondria Ca2+ influx from the endoplasmic reticulum to induce apoptosis in hepatocellular carcinoma cells

• Autor: Wang, Weilin ; Xie, Qingsong ; Zhou, Xiaohu ; Yao, Jingzi ; Zhu, Xiaoxiang ; Huang, Pengfei ; Zhang, Lufei ; Wei, Jianfeng ; Xie, Haiyang ; Zhou, Lin ; Zheng, Shusen
• Assuntos: Adenoviruses ; Aged ; Apoptosis ; Apoptosis - genetics ; Calcium - metabolism ; Carcinoma, Hepatocellular - genetics ; Carcinoma, Hepatocellular - metabolism ; Carcinoma, Hepatocellular - pathology ; Cytochrome ; Endoplasmic Reticulum - genetics ; Endoplasmic Reticulum - metabolism ; Endoplasmic Reticulum - pathology ; Female ; Gene Expression Regulation, Neoplastic - drug effects ; GTP Phosphohydrolases - antagonists & inhibitors ; GTP Phosphohydrolases - biosynthesis ; Hematology, Oncology and Palliative Medicine ; Hep G2 Cells ; Heparin ; Heparin - administration & dosage ; Homeostasis ; Humans ; InsP3R ; Liver cancer ; Liver Neoplasms - metabolism ; Liver Neoplasms - pathology ; Male ; Middle Aged ; Mitochondria ; Mitochondria - pathology ; Mitochondrial Ca2+ uniporter ; Mitochondrial calcium uptake 2 ; Mitochondrial calcium uptake1 ; Mitochondrial Proteins - antagonists & inhibitors ; Mitochondrial Proteins - biosynthesis ; Neoplasm Staging ; Proteins ; Reactive Oxygen Species - metabolism ; RU360 ; Ruthenium Compounds - administration & dosage
• É parte de: Cancer letters, 2015-03, Vol.358 (1), p.47-58
• Notas: ObjectType-Article-1
  SourceType-Scholarly Journals-1
  ObjectType-Feature-2
  content type line 23
  
• Descrição: Highlights • Mfn2 immunostaining is significantly associated with tumour size and TNM stage. • Patients with HCC with lower Mfn2 expression had a poorer prognosis. • Mfn2 induces cells apoptosis, declined ER Ca2+ , and elevated mitochondrial Ca2+. • Heparin and RU360 can changeover the above results. • Mfn2 downregulates the expresion of MICU1 and MICU2.
  
• Editor: Ireland: Elsevier Ireland Ltd
  
• Idioma: Inglês