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Trough Concentrations of Lopinavir, Nelfinavir, and Nevirapine With Standard Dosing in Human Immunodeficiency Virus-Infected Pregnant Women Receiving 3-Drug Combination Regimens

BARONCELLI, Silvia ; VILLANI, Paola ; TAMBURRINI, Enrica ; REGAZZI, Mario ; FLORIDIA, Marco ; PIRILLO, Maria F ; GALLUZZO, Clementina M ; CUSATO, Maria ; AMICI, Roberta ; PINNETTI, Carmela ; SABBATINI, Francesca ; MOLINARI, Atim

Therapeutic drug monitoring, 2008-10, Vol.30 (5), p.604-610 [Periódico revisado por pares]

Hagerstown, MD: Lippincott Williams & Wilkins

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Título:
Trough Concentrations of Lopinavir, Nelfinavir, and Nevirapine With Standard Dosing in Human Immunodeficiency Virus-Infected Pregnant Women Receiving 3-Drug Combination Regimens
Autor: BARONCELLI, Silvia ; VILLANI, Paola ; TAMBURRINI, Enrica ; REGAZZI, Mario ; FLORIDIA, Marco ; PIRILLO, Maria F ; GALLUZZO, Clementina M ; CUSATO, Maria ; AMICI, Roberta ; PINNETTI, Carmela ; SABBATINI, Francesca ; MOLINARI, Atim
Assuntos: Adolescent ; Adult ; Antiretroviral drugs ; Antiretroviral Therapy, Highly Active - standards ; Biological and medical sciences ; Cohort Studies ; Drug therapy ; Drug Therapy, Combination ; Female ; HIV ; HIV Infections - blood ; HIV Infections - complications ; HIV Infections - drug therapy ; Human immunodeficiency virus ; Human viral diseases ; Humans ; Immunodeficiencies ; Immunodeficiencies. Immunoglobulinopathies ; Immunopathology ; Infectious diseases ; Lopinavir ; Medical sciences ; Nelfinavir - administration & dosage ; Nelfinavir - blood ; Nelfinavir - standards ; Nevirapine - administration & dosage ; Nevirapine - blood ; Nevirapine - standards ; Pharmacology ; Pharmacology. Drug treatments ; Pregnancy ; Pregnancy Complications, Infectious - blood ; Pregnancy Complications, Infectious - drug therapy ; Pregnancy Complications, Infectious - virology ; Pyrimidinones - administration & dosage ; Pyrimidinones - blood ; Pyrimidinones - standards ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. Aids ; Viral Load - physiology ; Women ; Young Adult
É parte de: Therapeutic drug monitoring, 2008-10, Vol.30 (5), p.604-610
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
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Descrição: The objective of this study was to evaluate the plasma drug concentrations in human immunodeficiency virus (HIV)-infected pregnant women receiving highly active antiretroviral therapy (HAART) and to define the rate of occurrence of subtherapeutic concentrations for some commonly used antiretroviral drugs during pregnancy. We evaluated HIV-infected women (n = 68) in the third trimester of pregnancy in steady-state treatment with an HAART regimen administrated on a twice a day basis, which included 2 nucleoside reverse transcriptase inhibitors plus nelfinavir (NFV), lopinavir/ritonavir (LPV/r), or nevirapine (NVP). Blood samples were collected at predose (C(trough)). The following thresholds were used to define therapeutic drug concentrations-NFV: 0.8 microg/mL; LPV: 4.0 microg/mL/1.0 microg/mL (experienced/naive); and NVP: 3.1 microg/mL. At predose sampling, adequate drug concentrations were found in a higher proportion of women receiving NFV (70.8%) and LPV (75.0%) than NVP (55.6%). Median C(trough) plasma concentrations were 1.2 microg/mL for NFV, 5.5 microg/mL for LPV, and 3.1 microg/mL for NVP. Women receiving lopinavir/ritonavir had the lowest rates of detectable (>50 copies/mL) HIV RNA (15.4%) compared with rates of 22.2% and 41.7% among women receiving NVP and NFV, respectively. Genotypic resistance was detected in 50% of women with detectable HIV RNA for whom samples were available for testing. Subtherapeutic predose concentrations among HIV-infected pregnant women were more commonly found with NVP than with protease inhibitors. LPV administration was associated with the best viral load suppression.
Editor: Hagerstown, MD: Lippincott Williams & Wilkins
Idioma: Inglês

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Trough Concentrations of Lopinavir, Nelfinavir, and Nevirapine With Standard Dosing in Human Immunodeficiency Virus-Infected Pregnant Women Receiving 3-Drug Combination Regimens

BARONCELLI, Silvia ; VILLANI, Paola ; TAMBURRINI, Enrica ; REGAZZI, Mario ; FLORIDIA, Marco ; PIRILLO, Maria F ; GALLUZZO, Clementina M ; CUSATO, Maria ; AMICI, Roberta ; PINNETTI, Carmela ; SABBATINI, Francesca ; MOLINARI, Atim

Hagerstown, MD: Lippincott Williams & Wilkins

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