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Human Metapneumovirus and Lower Respiratory Tract Disease in Otherwise Healthy Infants and Children

Williams, John V ; Harris, Paul A ; Tollefson, Sharon J ; Halburnt-Rush, Lisa L ; Pingsterhaus, Joyce M ; Edwards, Kathryn M ; Wright, Peter F ; Crowe, James E

The New England journal of medicine, 2004-01, Vol.350 (5), p.443-450 [Periódico revisado por pares]

Boston, MA: Massachusetts Medical Society

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Título:
Human Metapneumovirus and Lower Respiratory Tract Disease in Otherwise Healthy Infants and Children
Autor: Williams, John V ; Harris, Paul A ; Tollefson, Sharon J ; Halburnt-Rush, Lisa L ; Pingsterhaus, Joyce M ; Edwards, Kathryn M ; Wright, Peter F ; Crowe, James E
Assuntos: Adolescent ; Adult ; Age of Onset ; Asthma - virology ; Biological and medical sciences ; Bronchiolitis - virology ; Child ; Child, Preschool ; Children ; Children & youth ; Clinical trials ; Female ; Human metapneumovirus ; Human viral diseases ; Humans ; Infant ; Infectious diseases ; Male ; Medical sciences ; Metapneumovirus - genetics ; Metapneumovirus - isolation & purification ; Paramyxoviridae Infections - complications ; Paramyxoviridae Infections - epidemiology ; Paramyxoviridae Infections - virology ; Phylogeny ; Pneumonia - virology ; Prospective Studies ; Recurrence ; Respiratory diseases ; Respiratory tract infections ; Respiratory Tract Infections - complications ; Respiratory Tract Infections - epidemiology ; Respiratory Tract Infections - virology ; RNA, Viral - analysis ; Viral diseases ; Viral diseases of the respiratory system and ent viral diseases ; Virus diseases ; Viruses
É parte de: The New England journal of medicine, 2004-01, Vol.350 (5), p.443-450
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SourceType-Scholarly Journals-1
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Descrição: In a large, prospective study of children with lower respiratory tract illness, human metapneumovirus was identified in 49 of 248 specimens (20 percent) that were negative for other pathogenic viruses. The mean age of the infected children was 11.6 months, and 59 percent had symptoms of bronchiolitis. This virus was isolated only rarely from asymptomatic children. A large study shows that human metapneumovirus is a leading cause of respiratory tract infection in young children. Respiratory syncytial virus (RSV), parainfluenza virus, adenovirus, and influenzavirus are common known causes of lower respiratory tract disease in infants and children. 1 – 3 Nevertheless, in a substantial portion of lower respiratory tract infections in children, no virus can be cultured. In 2001, researchers in the Netherlands isolated a new virus from children and adults with acute respiratory tract infection. 4 This RNA virus, provisionally designated human metapneumovirus, is closely related to avian pneumovirus. Since then, investigators in Canada, Australia, the United Kingdom, and the United States have described patients with acute respiratory tract infection due to human metapneumovirus. 5 – 8 We sought . . .
Editor: Boston, MA: Massachusetts Medical Society
Idioma: Inglês

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Human Metapneumovirus and Lower Respiratory Tract Disease in Otherwise Healthy Infants and Children

Williams, John V ; Harris, Paul A ; Tollefson, Sharon J ; Halburnt-Rush, Lisa L ; Pingsterhaus, Joyce M ; Edwards, Kathryn M ; Wright, Peter F ; Crowe, James E

Boston, MA: Massachusetts Medical Society

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