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Ferritin levels in the cerebrospinal fluid predict Alzheimer's disease outcomes and are regulated by APOE

Ayton, Scott ; Faux, Noel G ; Bush, Ashley I

Nature communications, 2015-05, Vol.6 (1), p.6760-6760, Article 6760 [Periódico revisado por pares]

England: Nature Publishing Group

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Ferritin levels in the cerebrospinal fluid predict Alzheimer's disease outcomes and are regulated by APOE
Autor: Ayton, Scott ; Faux, Noel G ; Bush, Ashley I
Assuntos: Aged ; Aged, 80 and over ; Alzheimer Disease - cerebrospinal fluid ; Apolipoproteins E - genetics ; Atrophy ; Brain - metabolism ; Cognition ; Cognition Disorders - cerebrospinal fluid ; Cohort Studies ; Databases, Factual ; Female ; Ferritins - cerebrospinal fluid ; Gene Expression Regulation ; Genotype ; Humans ; Iron - cerebrospinal fluid ; Longitudinal Studies ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Risk Factors ; Treatment Outcome
É parte de: Nature communications, 2015-05, Vol.6 (1), p.6760-6760, Article 6760
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
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These authors contributed equally to this work
Descrição: Brain iron elevation is implicated in Alzheimer's disease (AD) pathogenesis, but the impact of iron on disease outcomes has not been previously explored in a longitudinal study. Ferritin is the major iron storage protein of the body; by using cerebrospinal fluid (CSF) levels of ferritin as an index, we explored whether brain iron status impacts longitudinal outcomes in the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort. We show that baseline CSF ferritin levels were negatively associated with cognitive performance over 7 years in 91 cognitively normal, 144 mild cognitive impairment (MCI) and 67 AD subjects, and predicted MCI conversion to AD. Ferritin was strongly associated with CSF apolipoprotein E levels and was elevated by the Alzheimer's risk allele, APOE-ɛ4. These findings reveal that elevated brain iron adversely impacts on AD progression, and introduce brain iron elevation as a possible mechanism for APOE-ɛ4 being the major genetic risk factor for AD.
Editor: England: Nature Publishing Group
Idioma: Inglês

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Ferritin levels in the cerebrospinal fluid predict Alzheimer's disease outcomes and are regulated by APOE

Ayton, Scott ; Faux, Noel G ; Bush, Ashley I

England: Nature Publishing Group

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