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Prognosis of gastrointestinal smooth-muscle (stromal) tumors : Dependence on anatomic site

EMORY, T. S ; SOBIN, L. H ; LUKES, L ; LEE, D. H ; O'LEARY, T. J

The American journal of surgical pathology, 1999, Vol.23 (1), p.82-87 [Periódico revisado por pares]

Hagerstown, MD: Lippincott Williams & Wilkins

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Título:
Prognosis of gastrointestinal smooth-muscle (stromal) tumors : Dependence on anatomic site
Autor: EMORY, T. S ; SOBIN, L. H ; LUKES, L ; LEE, D. H ; O'LEARY, T. J
Assuntos: Adolescent ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Child ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Gastrointestinal Neoplasms - mortality ; Gastrointestinal Neoplasms - pathology ; Humans ; Male ; Medical sciences ; Middle Aged ; Mitotic Index ; Prognosis ; Proportional Hazards Models ; Retrospective Studies ; Smooth Muscle Tumor - mortality ; Smooth Muscle Tumor - pathology ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Stromal Cells - pathology ; Survival Analysis ; Survival Rate ; Tumors
É parte de: The American journal of surgical pathology, 1999, Vol.23 (1), p.82-87
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: Although the significance of various prognostic factors, such as tumor size and mitotic index (MI), has been well established for smooth-muscle tumors of the stomach, the significance of these factors in other sites is less well defined. We studied 1004 patients with gastrointestinal smooth-muscle tumors for whom vital status could be determined. The average MI and tumor size varied significantly among the five major sites examined: esophagus (53 cases), stomach (524 cases), small bowel 252 cases), colon/rectum (108 cases), and omentum/mesentery/peritoneum (67 cases). There was a significant difference in site-specific survival (p = 0.001), with 10-year survival varying between 50% and 70%. Multivariate analysis demonstrated tumor location (p = 0.0320), size (p = 0.0003), MI (p < 0.0001), and patient age (p < 0.0001) to each carry independent prognostic value. The significance of MI was highly site dependent. Separation of survival curves for the stomach, using a threshold for analysis of either 5 or 10 mitotic figures/50 high-power fields, was very good. In contrast, small-bowel tumors showed little separation between survival curves, regardless of whether a threshold of 1, 5, or 10 mitotic figures MF/50 high-power fields was used to distinguish groups. In no site were tumor size and MI alone sufficient to provide an accurate long-term prediction of prognosis. Although tumor location, size, MI, and age have independent value in predicting the prognosis of patients with gastrointestinal smooth-muscle tumors, better methods are still required to accurately predict clinical course.
Editor: Hagerstown, MD: Lippincott Williams & Wilkins
Idioma: Inglês

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Prognosis of gastrointestinal smooth-muscle (stromal) tumors : Dependence on anatomic site

EMORY, T. S ; SOBIN, L. H ; LUKES, L ; LEE, D. H ; O'LEARY, T. J

Hagerstown, MD: Lippincott Williams & Wilkins

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