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13q14 deletion in non-Hodgkin's lymphoma: correlation with clinicopathologic features

Cuneo, A ; Bigoni, R ; Rigolin, GM ; Roberti, MG ; Bardi, A ; Campioni, D ; Minotto, C ; Agostini, P ; Milani, R ; Bullrich, F ; Negrini, M ; Croce, C ; Castoldi, G

Haematologica (Roma), 1999-07, Vol.84 (7), p.589-593 [Periódico revisado por pares]

Italy

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Título:
13q14 deletion in non-Hodgkin's lymphoma: correlation with clinicopathologic features
Autor: Cuneo, A ; Bigoni, R ; Rigolin, GM ; Roberti, MG ; Bardi, A ; Campioni, D ; Minotto, C ; Agostini, P ; Milani, R ; Bullrich, F ; Negrini, M ; Croce, C ; Castoldi, G
Assuntos: Biomarkers, Tumor ; Chromosomes, Human, Pair 13 ; Gene Rearrangement ; Genes, Retinoblastoma ; Humans ; Karyotyping ; Lymphoma, Non-Hodgkin - genetics ; Lymphoma, Non-Hodgkin - physiopathology ; Multivariate Analysis ; Prognosis ; Sequence Deletion
É parte de: Haematologica (Roma), 1999-07, Vol.84 (7), p.589-593
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Istituto di Ematologia, Universita di Ferrara, via Savonarola 9, 44100 Ferrara, Italy. sse@dns.unife.it BACKGROUND AND OBJECTIVE: 13q14 deletion frequently occurs as a single anomaly in chronic lymphocytic leukemia (CLL) with favorable prognosis. This study was performed to assess the distribution of 13q14 deletion in non-Hodgkin's lymphoma (NHL) and to analyze its correlation with salient clinicopathologic features. DESIGN AND METHODS: One hundred and twenty-five NHL were analyzed by cytogenetics and by interphase fluorescence in situ hybridization (FISH), using a 13q14 cosmid probe recognizing DNA sequences between the Rb gene and the D13S25 marker. Clinical records all patients were surveyed. RESULTS: A 13q14 rearrangement was present in the stemline in 10 patients; 15 additional cases were shown by FISH to carry 13q14 deletion in 55-90% of the interphase cells, giving a 20% overall incidence for this anomaly. Six of 44 patients had a low-grade NHL, 14/28 had mantle cell lymphoma (MCL), 5/42 had a high grade NHL (p
Editor: Italy
Idioma: Inglês

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13q14 deletion in non-Hodgkin's lymphoma: correlation with clinicopathologic features

Cuneo, A ; Bigoni, R ; Rigolin, GM ; Roberti, MG ; Bardi, A ; Campioni, D ; Minotto, C ; Agostini, P ; Milani, R ; Bullrich, F ; Negrini, M ; Croce, C ; Castoldi, G

Italy

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