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Neutrophils self-limit swarming to contain bacterial growth in vivo

Kienle, Korbinian ; Glaser, Katharina M ; Eickhoff, Sarah ; Mihlan, Michael ; Knöpper, Konrad ; Reátegui, Eduardo ; Epple, Maximilian W ; Gunzer, Matthias ; Baumeister, Ralf ; Tarrant, Teresa K ; Germain, Ronald N ; Irimia, Daniel ; Kastenmüller, Wolfgang ; Lämmermann, Tim

Science (American Association for the Advancement of Science), 2021-06, Vol.372 (6548) [Periódico revisado por pares]

United States: The American Association for the Advancement of Science

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Título:
Neutrophils self-limit swarming to contain bacterial growth in vivo
Autor: Kienle, Korbinian ; Glaser, Katharina M ; Eickhoff, Sarah ; Mihlan, Michael ; Knöpper, Konrad ; Reátegui, Eduardo ; Epple, Maximilian W ; Gunzer, Matthias ; Baumeister, Ralf ; Tarrant, Teresa K ; Germain, Ronald N ; Irimia, Daniel ; Kastenmüller, Wolfgang ; Lämmermann, Tim
Assuntos: Accumulation ; Agglomeration ; Amplification ; Animals ; Antiinfectives and antibacterials ; Attractants ; b-Adrenergic-receptor kinase ; Bacteria ; Cell Aggregation ; Cell interactions ; Cell signaling ; Cell surface ; Chemokine CXCL2 ; Chemotactic factors ; Chemotaxis ; Chemotaxis, Leukocyte ; Clearances ; Clustering ; Containment ; Control systems ; Desensitization ; Eosinophils - physiology ; Feedback ; Feedback (Response) ; Feedback control ; Female ; G protein-coupled receptors ; G-Protein-Coupled Receptor Kinase 2 - genetics ; G-Protein-Coupled Receptor Kinase 2 - metabolism ; Group Behavior ; Immune clearance ; Immune response ; Immune system ; Inflammation ; Innate immunity ; Insects ; Isoforms ; Kinases ; Leukocyte migration ; Leukocytes (neutrophilic) ; Leukotriene B4 - metabolism ; Lymph nodes ; Lymph Nodes - microbiology ; Male ; Mice ; Mice, Transgenic ; Migration ; Navigation ; Negative feedback ; Neutrophils ; Neutrophils - immunology ; Neutrophils - physiology ; Numbers ; Organs ; Phagocytosis ; Positive feedback ; Proteins ; Pseudomonas aeruginosa ; Pseudomonas aeruginosa - growth & development ; Pseudomonas Infections - immunology ; Pseudomonas Infections - microbiology ; Receptors ; Receptors, G-Protein-Coupled - metabolism ; Shutdowns ; Signal processing ; Signal Transduction ; Skin - immunology ; Skin - injuries ; Skin - pathology ; Swarming ; Swarming behavior ; Tissues ; Transgenic mice
É parte de: Science (American Association for the Advancement of Science), 2021-06, Vol.372 (6548)
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Author contributions: K.Ki. and K.M.G.: conceptualization, investigation, methodology, validation, formal analysis, visualization, and writing review and editing; K.M.G.: software; S.E. and K.Kn.: investigation and methodology; M.M. and M.W.E.: investigation; M.G., R.B., T.K.T.: resources; R.N.G.: writing review and editing; E.R. and D.I.: resources, methodology; W.K.: methodology and writing review and editing; T.L.: conceptualization, funding acquisition, project administration, supervision, investigation, formal analysis, methodology, visualization, writing original draft; ICMJE guidelines were taken into consideration.
Descrição: Neutrophils communicate with each other to form swarms in infected organs. Coordination of this population response is critical for the elimination of bacteria and fungi. Using transgenic mice, we found that neutrophils have evolved an intrinsic mechanism to self-limit swarming and avoid uncontrolled aggregation during inflammation. G protein-coupled receptor (GPCR) desensitization acts as a negative feedback control to stop migration of neutrophils when they sense high concentrations of self-secreted attractants that initially amplify swarming. Interference with this process allows neutrophils to scan larger tissue areas for microbes. Unexpectedly, this does not benefit bacterial clearance as containment of proliferating bacteria by neutrophil clusters becomes impeded. Our data reveal how autosignaling stops self-organized swarming behavior and how the finely tuned balance of neutrophil chemotaxis and arrest counteracts bacterial escape.
Editor: United States: The American Association for the Advancement of Science
Idioma: Inglês

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Neutrophils self-limit swarming to contain bacterial growth in vivo

Kienle, Korbinian ; Glaser, Katharina M ; Eickhoff, Sarah ; Mihlan, Michael ; Knöpper, Konrad ; Reátegui, Eduardo ; Epple, Maximilian W ; Gunzer, Matthias ; Baumeister, Ralf ; Tarrant, Teresa K ; Germain, Ronald N ; Irimia, Daniel ; Kastenmüller, Wolfgang ; Lämmermann, Tim

United States: The American Association for the Advancement of Science

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