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Central mediators involved in the febrile response induced by polyinosinic–polycytidylic acid: Lack of involvement of endothelins and substance P

Bastos-Pereira, A.L ; Leite, M.C.G ; Fraga, D ; Zampronio, A.R

Journal of neuroimmunology, 2015-01, Vol.278, p.100-107 [Periódico revisado por pares]

Netherlands: Elsevier B.V

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Título:
Central mediators involved in the febrile response induced by polyinosinic–polycytidylic acid: Lack of involvement of endothelins and substance P
Autor: Bastos-Pereira, A.L ; Leite, M.C.G ; Fraga, D ; Zampronio, A.R
Assuntos: Allergy and Immunology ; Animals ; Anti-Inflammatory Agents, Non-Steroidal ; Antibodies - therapeutic use ; Body Temperature - drug effects ; Celecoxib ; Central Nervous System - drug effects ; Central Nervous System - metabolism ; Cytokine ; Cytokines - immunology ; Cytokines - metabolism ; Dinoprostone - metabolism ; Endothelin ; Endothelin B Receptor Antagonists - therapeutic use ; Fever - chemically induced ; Indomethacin - therapeutic use ; Interferon Inducers - toxicity ; Male ; Neurology ; Oligopeptides - therapeutic use ; Opioids ; Peptides ; Piperidines - therapeutic use ; Poly I-C - toxicity ; Poly I:C ; Prostaglandin ; Pyrazoles - therapeutic use ; Rats ; Rats, Wistar ; Substance P ; Sulfonamides - therapeutic use ; Tropanes - therapeutic use
É parte de: Journal of neuroimmunology, 2015-01, Vol.278, p.100-107
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SourceType-Scholarly Journals-1
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Descrição: Abstract The present study evaluated the involvement of interleukin(IL)-1β, tumor necrosis factor-α (TNF-α), IL-6, interferon(IFN)-γ, prostaglandins of the E2 series, endothelins, substance P and opioids within the central nervous system in polyinosinic:polycytidylic acid (Poly I:C)-induced fever in rats. Poly I:C injection induced a febrile response which was reduced by intracerebroventricular administration of the antibodies against TNF-α, IL-6, or IFN-γ, or by IL-1 or μ receptor antagonists. Intraperitoneal injection of indomethacin or oral administration of celecoxib also reduced Poly I:C-induced fever. Poly I:C increased prostaglandin E2 levels in the cerebrospinal fluid of the animals which was also reduced by indomethacin. The intracerebroventricular injection of ETB or NK1 receptor antagonists did not alter Poly I:C-induced fever. These data suggest the involvement of IL-1β, TNF-α, IL-6, IFN-γ, prostaglandin E2 , and opioids but not endothelins and substance P on Poly I:C-induced fever.
Editor: Netherlands: Elsevier B.V
Idioma: Inglês

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Central mediators involved in the febrile response induced by polyinosinic–polycytidylic acid: Lack of involvement of endothelins and substance P

Bastos-Pereira, A.L ; Leite, M.C.G ; Fraga, D ; Zampronio, A.R

Netherlands: Elsevier B.V

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